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Summary Expression Phenotypes Gene Literature (677) GO Terms (3) Nucleotides (94) Proteins (51) Interactants (1024) Wiki
XB-GENEPAGE-485904

Papers associated with ins



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A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life., Vedovato N, Salguero MV, Greeley SAW, Yu CH, Philipson LH, Ashcroft FM., Diabetologia. May 1, 2024; 67 (5): 940-951.          

Amphibian host-defense peptides with potential for Type 2 diabetes therapy - an updated review., Conlon JM, Owolabi BO, Flatt PR, Abdel-Wahab YHA., Peptides. February 22, 2024; 175 171180.  

Isthmin: A multifunctional secretion protein., Liang JY, Wei HJ, Tang YY., Cytokine. January 1, 2024; 173 156423.

Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos., Azbazdar Y, Pera EM, De Robertis EM., Cells Dev. December 16, 2023; 203897.                  

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling., Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E., Nat Commun. October 5, 2023; 14 (1): 6173.                                

Molecular cloning, tissues distribution, and function analysis of thioredoxin-like protein-1 (TXNL1) in Chinese giant salamanders Andrias davidianus., Mo H, Yu H, Jiang Z, Chen Y, Yao M, Liu K, Li Y, Yu J, Wang L., Dev Comp Immunol. July 1, 2023; 144 104691.            

Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism., Zhang S, Fu C, Luo Y, Xie Q, Xu T, Sun Z, Su Z, Zhou X., J Struct Biol. March 1, 2023; 215 (1): 107926.

Genetic and Physiological Effects of Insulin-Like Growth Factor-1 (IGF-1) on Human Urate Homeostasis., Mandal AK, Leask MP, Sumpter NA, Choi HK, Merriman TR, Mount DB., J Am Soc Nephrol. March 1, 2023; 34 (3): 451-466.

Role of FOXO transcription factors in the tolerance of whole-body freezing in the wood frog, Rana sylvatica., Rehman S, Hadj-Moussa H, Hawkins L, Storey KB., Cryobiology. March 1, 2023; 110 44-48.

Metamorphic gene regulation programs in Xenopus tropicalis tadpole brain., Raj S, Sifuentes CJ, Kyono Y, Denver RJ., PLoS One. January 1, 2023; 18 (6): e0287858.                

Peptides Isolated from Amphibian Skin Secretions with Emphasis on Antimicrobial Peptides., Chen X, Liu S, Fang J, Zheng S, Wang Z, Jiao Y, Xia P, Wu H, Ma Z, Hao L., Toxins (Basel). October 21, 2022; 14 (10):   

An amphibian high fat diet model confirms that endocrine disruptors can induce a metabolic syndrome in wild green frogs (Pelophylax spp. complex)., Veyrenc S, Regnault C, Sroda S, Raveton M, Reynaud S., Environ Pollut. October 15, 2022; 311 120009.

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna., Shindyapina AV, Cho Y, Kaya A, Tyshkovskiy A, Castro JP, Deik A, Gordevicius J, Poganik JR, Clish CB, Horvath S, Peshkin L, Gladyshev VN., Sci Adv. September 16, 2022; 8 (37): eabo5482.

A GLP-1/glucagon (GCG)/CCK2 receptors tri-agonist provides new therapy for obesity and diabetes., Zhao S, Yan Z, Du Y, Li Z, Tang C, Jing L, Sun L, Yang Q, Tang X, Yuan Y, Han J, Jiang N., Br J Pharmacol. September 1, 2022; 179 (17): 4360-4377.

Insulin Receptor-Related Receptor Regulates the Rate of Early Development in Xenopus laevis., Korotkova DD, Gantsova EA, Goryashchenko AS, Eroshkin FM, Serova OV, Sokolov AS, Sharko F, Zhenilo SV, Martynova NY, Petrenko AG, Zaraisky AG, Deyev IE., Int J Mol Sci. August 17, 2022; 23 (16):                     

Discovery of once-weekly, peptide-based selective GLP-1 and cholecystokinin 2 receptors co-agonizts., Zhou F, Song P, Tang X, Yang Q, Zhou S, Xu R, Fang T, Jia Z, Han J., Peptides. July 1, 2022; 153 170811.

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates., Szenker-Ravi E, Ott T, Khatoo M, Moreau de Bellaing A, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B., Nat Genet. January 1, 2022; 54 (1): 62-72.

Stapled, Long-Acting Xenopus GLP-1-Based Dual GLP-1/Glucagon Receptor Agonists with Potent Therapeutic Efficacy for Metabolic Disease., Han C, Sun Y, Yang Q, Zhou F, Chen X, Wu L, Sun L, Han J., Mol Pharm. August 2, 2021; 18 (8): 2906-2923.

Functional rice with tandemly repeated Cbl-b ubiquitin ligase inhibitory pentapeptide prevents denervation-induced muscle atrophy in vivo., Akama K, Shimajiri Y, Kainou K, Iwasaki R, Nakao R, Nikawa T, Nishikawa A., Biosci Biotechnol Biochem. May 25, 2021; 85 (6): 1415-1421.

Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., Musale V, Moffett RC, Conlon JM, Flatt PR, Abdel-Wahab YH., Peptides. February 1, 2021; 136 170472.

Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis., Usal M, Veyrenc S, Darracq-Ghitalla-Ciock M, Regnault C, Sroda S, Fini JB, Canlet C, Tremblay-Franco M, Raveton M, Reynaud S., Environ Pollut. January 15, 2021; 269 116109.

Genetic and Physiological Effects of Insulin on Human Urate Homeostasis., Mandal AK, Leask MP, Estiverne C, Choi HK, Merriman TR, Mount DB., Front Physiol. January 1, 2021; 12 713710.              

X-box-binding protein 1 is required for pancreatic development in Xenopus laevis., Yang J, Liu X, Yuan F, Liu J, Li D, Wei L, Wang X, Yuan L., Acta Biochim Biophys Sin (Shanghai). December 11, 2020; 52 (11): 1215-1226.                  

Inhibition of the facilitative sugar transporters (GLUTs) by tea extracts and catechins., Ni D, Ai Z, Munoz-Sandoval D, Suresh R, Ellis PR, Yuqiong C, Sharp PA, Butterworth PJ, Yu Z, Corpe CP., FASEB J. August 1, 2020; 34 (8): 9995-10010.

Interactive Actions of Aldosterone and Insulin on Epithelial Na+ Channel Trafficking., Marunaka R, Marunaka Y., Int J Mol Sci. May 12, 2020; 21 (10):         

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel., Tóth B, Iordanov I, Csanády L., J Gen Physiol. May 4, 2020; 152 (5):


Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors., Leippe P, Broichhagen J, Cailliau K, Mougel A, Morel M, Dissous C, Trauner D, Vicogne J., Angew Chem Int Ed Engl. April 20, 2020; 59 (17): 6720-6723.

Biochemical responses revealed in an amphibian species after exposure to a forgotten contaminant: An integrated biomarker assessment., Dahms-Verster S, Nel A, van Vuren JHJ, Greenfield R., Environ Toxicol Pharmacol. January 1, 2020; 73 103272.

Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism., Choukair D, Eberle B, Vick P, Hermanns P, Weiss B, Paramasivam N, Schlesner M, Lornsen K, Roeth R, Klutmann C, Kreis J, Hoffmann GF, Pohlenz J, Rappold GA, Bettendorf M., Horm Res Paediatr. January 1, 2020; 93 (1): 16-29.

Concomitant exposure to benzo[a]pyrene and triclosan at environmentally relevant concentrations induces metabolic syndrome with multigenerational consequences in Silurana (Xenopus) tropicalis., Usal M, Regnault C, Veyrenc S, Couturier K, Batandier C, Bulteau AL, Lejon D, Combourieu B, Lafond T, Raveton M, Reynaud S., Sci Total Environ. November 1, 2019; 689 149-159.

Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors., McKeown CR, Cline HT., Development. October 24, 2019; 146 (20):             

Phosphoinositides modulate the voltage dependence of two-pore channel 3., Shimomura T, Kubo Y., J Gen Physiol. August 5, 2019; 151 (8): 986-1006.                              

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates., Iordanov I, Tóth B, Szollosi A, Csanády L., Elife. April 2, 2019; 8                     

Ketone body modulation of ligand-gated ion channels., Pflanz NC, Daszkowski AW, James KA, Mihic SJ., Neuropharmacology. April 1, 2019; 148 21-30.

Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation., Haworth K, Samuel L, Black S, Kirilenko P, Latinkic B., Front Physiol. January 1, 2019; 10 155.              

Identification of retinal homeobox (rax) gene-dependent genes by a microarray approach: The DNA endoglycosylase neil3 is a major downstream component of the rax genetic pathway., Pan Y, Kelly LE, El-Hodiri HM., Dev Dyn. November 1, 2018; 247 (11): 1199-1210.                            

A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel., Ramu Y, Xu Y, Xu Y, Lu Z., J Gen Physiol. July 2, 2018; 150 (7): 969-976.              

Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment., Misra S, Vedovato N, Cliff E, De Franco E, Hattersley AT, Ashcroft FM, Oliver NS., Diabet Med. June 13, 2018;


Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis., Gere-Becker MB, Pommerenke C, Lingner T, Pieler T., Development. June 8, 2018; 145 (12):                                   

Binding of sulphonylureas to plasma proteins - A KATP channel perspective., Proks P, Kramer H, Haythorne E, Ashcroft FM., PLoS One. May 15, 2018; 13 (5): e0197634.        

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation., Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L., Elife. May 10, 2018; 7                         

Unexpected metabolic disorders induced by endocrine disruptors in Xenopus tropicalis provide new lead for understanding amphibian decline., Regnault C, Usal M, Veyrenc S, Couturier K, Batandier C, Bulteau AL, Lejon D, Sapin A, Combourieu B, Chetiveaux M, Le May C, Lafond T, Raveton M, Reynaud S., Proc Natl Acad Sci U S A. May 8, 2018; 115 (19): E4416-E4425.        

A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals., Zhang Y, Qin C, Yang L, Lu R, Zhao X, Nie G., BMC Genomics. April 11, 2018; 19 (1): 246.          

Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities., Han J, Fei Y, Zhou F, Chen X, Zhang Y, Liu L, Fu J., Br J Pharmacol. February 1, 2018; 175 (3): 544-557.

Isolation and Primary Culture Methods of Adult and Larval Myogenic Cells from Xenopus laevis., Taheruzzaman K, Nishikawa A., Methods Mol Biol. January 1, 2018; 1865 283-299.

Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model., Marunaka R, Taruno A, Yamamoto T, Kanamura N, Marunaka Y., Cell Physiol Biochem. January 1, 2018; 50 (1): 363-377.

Regulation of the insulin-Akt signaling pathway and glycolysis during dehydration stress in the African clawed frog Xenopus laevis., Wu CW, Tessier SN, Storey KB., Biochem Cell Biol. December 1, 2017; 95 (6): 663-671.

Differential cytolocation and functional assays of the two major human SLC30A8 (ZnT8) isoforms., Carvalho S, Molina-López J, Parsons D, Corpe C, Maret W, Hogstrand C., J Trace Elem Med Biol. December 1, 2017; 44 116-124.

Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression., Wu M, Obara Y, Ohshima S, Nagasawa Y, Ishii K., Biochem Biophys Res Commun. November 4, 2017; 493 (1): 409-415.

Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women., Castro-Acosta ML, Stone SG, Mok JE, Mhajan RK, Fu CI, Lenihan-Geels GN, Corpe CP, Hall WL., J Nutr Biochem. November 1, 2017; 49 53-62.

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