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Summary Expression Phenotypes Gene Literature (154) GO Terms (9) Nucleotides (134) Proteins (60) Interactants (487) Wiki
XB-GENEPAGE-491845

Papers associated with chek1



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The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts., Kumagai A, Guo Z, Emami KH, Wang SX, Dunphy WG., J Cell Biol. September 21, 1998; 142 (6): 1559-69.            

Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes., Nakajo N, Oe T, Uto K, Sagata N., Dev Biol. March 15, 1999; 207 (2): 432-44.

Substrate specificity determinants of the checkpoint protein kinase Chk1., Hutchins JR, Hughes M, Clarke PR., FEBS Lett. January 21, 2000; 466 (1): 91-5.

Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends., Guo Z, Dunphy WG., Mol Biol Cell. May 1, 2000; 11 (5): 1535-46.

Dissection of the XChk1 signaling pathway in Xenopus laevis embryos., Kappas NC, Savage P, Chen KC, Walls AT, Sible JC., Mol Biol Cell. September 1, 2000; 11 (9): 3101-8.

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts., Kumagai A, Dunphy WG., Mol Cell. October 1, 2000; 6 (4): 839-49.

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts., Guo Z, Kumagai A, Wang SX, Dunphy WG., Genes Dev. November 1, 2000; 14 (21): 2745-56.

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint., Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA., Curr Biol. December 1, 2000; 10 (24): 1565-73.

Activation of Xenopus Chk1 by mutagenesis of threonine-377., Wang SX, Dunphy WG., FEBS Lett. December 29, 2000; 487 (2): 277-81.

Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes., Oe T, Nakajo N, Katsuragi Y, Okazaki K, Sagata N., Dev Biol. January 1, 2001; 229 (1): 250-61.

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins., Lee J, Kumagai A, Dunphy WG., Mol Biol Cell. March 1, 2001; 12 (3): 551-63.

Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G(2)/M-phase transition in Xenopus oocytes., Gotoh T, Ohsumi K, Matsui T, Takisawa H, Kishimoto T., J Cell Sci. September 1, 2001; 114 (Pt 18): 3397-406.

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition., Kang D, Chen J, Wong J, Fang G., J Cell Biol. January 21, 2002; 156 (2): 249-59.                

Signalling pathways in oocyte meiotic maturation., Schmitt A, Nebreda AR., J Cell Sci. June 15, 2002; 115 (Pt 12): 2457-9.  

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition., Shimuta K, Nakajo N, Uto K, Hayano Y, Okazaki K, Sagata N., EMBO J. July 15, 2002; 21 (14): 3694-703.

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint., You Z, Kong L, Newport J., J Biol Chem. July 26, 2002; 277 (30): 27088-93.

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts., Stokes MP, Van Hatten R, Lindsay HD, Michael WM., J Cell Biol. September 2, 2002; 158 (5): 863-72.        

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint., Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA., Genes Dev. September 15, 2002; 16 (18): 2327-32.

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus., McGarry TJ., Mol Biol Cell. October 1, 2002; 13 (10): 3662-71.            

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest., Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC., J Cell Sci. December 1, 2002; 115 (Pt 23): 4555-64.

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17., Lee J, Lee J, Kumagai A, Dunphy WG., Mol Cell. February 1, 2003; 11 (2): 329-40.

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1., Kumagai A, Dunphy WG., Nat Cell Biol. February 1, 2003; 5 (2): 161-5.

Loss of XChk1 function triggers apoptosis after the midblastula transition in Xenopus laevis embryos., Carter AD, Sible JC, Sible JC., Mech Dev. March 1, 2003; 120 (3): 315-23.            

Expression of cell-cycle regulators during Xenopus oogenesis., Furuno N, Kawasaki A, Sagata N., Gene Expr Patterns. May 1, 2003; 3 (2): 165-8.        

Human claspin is required for replication checkpoint control., Chini CC, Chen J., J Biol Chem. August 8, 2003; 278 (32): 30057-62.

XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus., Jones RE, Chapman JR, Puligilla C, Murray JM, Car AM, Ford CC, Lindsay HD., Mol Biol Cell. September 1, 2003; 14 (9): 3898-910.

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II., Hutchins JR, Dikovskaya D, Clarke PR., Mol Biol Cell. October 1, 2003; 14 (10): 4003-14.

DNA damage-induced replication arrest in Xenopus egg extracts., Stokes MP, Michael WM., J Cell Biol. October 27, 2003; 163 (2): 245-55.                

Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin., Parrilla-Castellar ER, Karnitz LM., J Biol Chem. November 14, 2003; 278 (46): 45507-11.

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation., Jeong SY, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 21, 2003; 278 (47): 46782-8.

Claspin, a regulator of Chk1 in DNA replication stress pathway., Chini CC, Chen J., DNA Repair (Amst). January 1, 2004; 3 (8-9): 1033-7.

Altered expression of Chk1 disrupts cell cycle remodeling at the midblastula transition in Xenopus laevis embryos., Petrus MJ, Wilhelm DE, Murakami M, Kappas NC, Carter AD, Wroble BN, Sible JC., Cell Cycle. February 1, 2004; 3 (2): 212-7.

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation., Katsuragi Y, Sagata N., Mol Biol Cell. April 1, 2004; 15 (4): 1680-9.

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation., Oehlmann M, Score AJ, Blow JJ., J Cell Biol. April 26, 2004; 165 (2): 181-90.                  

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation., Lin SY, Li K, Stewart GS, Elledge SJ., Proc Natl Acad Sci U S A. April 27, 2004; 101 (17): 6484-9.

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. May 28, 2004; 117 (5): 575-88.

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases., Li W, Kim SM, Lee J, Lee J, Dunphy WG., J Cell Biol. June 21, 2004; 165 (6): 801-12.                

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication., Jares P, Luciani MG, Blow JJ., BMC Mol Biol. June 28, 2004; 5 5.          

ATR and ATM regulate the timing of DNA replication origin firing., Shechter D, Costanzo V, Gautier J., Nat Cell Biol. July 1, 2004; 6 (7): 648-55.

The DNA damage checkpoint in embryonic cell cycles is dependent on the DNA-to-cytoplasmic ratio., Conn CW, Lewellyn AL, Maller JL., Dev Cell. August 1, 2004; 7 (2): 275-81.

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism., Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N., EMBO J. August 18, 2004; 23 (16): 3386-96.

Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity., Benjamin JM, Torke SJ, Demeler B, McGarry TJ., J Biol Chem. October 29, 2004; 279 (44): 45957-68.

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1., Kumagai A, Kim SM, Dunphy WG., J Biol Chem. November 26, 2004; 279 (48): 49599-608.

Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus., Luciani MG, Oehlmann M, Blow JJ., J Cell Sci. December 1, 2004; 117 (Pt 25): 6019-30.

Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable., de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC., J Cell Sci. May 1, 2005; 118 (Pt 9): 1833-42.

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint., Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA., Genes Dev. May 1, 2005; 19 (9): 1040-52.

Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases., Kanemori Y, Uto K, Sagata N., Proc Natl Acad Sci U S A. May 3, 2005; 102 (18): 6279-84.

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system., Clarke CA, Clarke PR., Biochem J. June 1, 2005; 388 (Pt 2): 705-12.

Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2., Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S., Cell. October 7, 2005; 123 (1): 89-103.

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway., Clarke CA, Bennett LN, Clarke PR., J Biol Chem. October 21, 2005; 280 (42): 35337-45.

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