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Summary Expression Phenotypes Gene Literature (161) GO Terms (14) Nucleotides (553) Proteins (65) Interactants (344) Wiki
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Papers associated with tpx2



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Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors., Zhu M, Wang X, Zhang Q, Xie C, Wang T, Shen K, Zhang L, Zhou X., Aging (Albany NY). February 2, 2024; 16 (3): 2563-2590.

[miR-218-5p Targeting TPX2 Regulates p53 Pathway and Inhibits Malignant Progression of Lung Adenocarcinoma]., Xu J., Zhongguo Fei Ai Za Zhi. October 20, 2023; 26 (10): 721-731.

TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer., Guenther M, Surendran SA, Haas M, Heinemann V, von Bergwelt-Baildon M, Engel J, Werner J, Boeck S, Ormanns S., Br J Cancer. July 1, 2023; 129 (1): 175-182.      

Augmin is a Ran-regulated spindle assembly factor., Kraus J, Travis SM, King MR, Petry S., J Biol Chem. June 1, 2023; 299 (6): 104736.            

TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs., Wang H, Chu F, Zhang XF, Zhang P, Li LX, Zhuang YL, Niu XF, He X, Li ZJ, Bai Y, Mao D, Liu ZW, Zhang DL, Li BA., Cell Death Dis. January 27, 2023; 14 (1): 64.

Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel., Hu J, He Q, Tian T, Chang N, Qian L., Onco Targets Ther. January 1, 2023; 16 197-210.

The translation regulator Zar1l controls timing of meiosis in Xenopus oocytes., Heim A, Niedermeier ML, Stengel F, Mayer TU., Development. November 1, 2022; 149 (21):                           

LncRNA KCNQ1OT1 enhances the radioresistance of lung squamous cell carcinoma by targeting the miR-491-5p/TPX2-RNF2 axis., Liu J, Jiang M, Guan J, Wang Y, Yu W, Hu Y, Zhang X, Yang J., J Thorac Dis. October 1, 2022; 14 (10): 4081-4095.

TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway., Zhu D, Xu X, Zhang M, Wang T., Oncol Lett. May 1, 2022; 23 (5): 143.

Target Protein for Xklp2 Functions as Coactivator of Androgen Receptor and Promotes the Proliferation of Prostate Carcinoma Cells., Sun B, Long Y, Xiao L, Wang J, Yi Q, Tong D, Li K., J Oncol. April 11, 2022; 2022 6085948.

TPX2 is a prognostic marker and promotes cell proliferation in neuroblastoma., Koike Y, Yin C, Sato Y, Nagano Y, Yamamoto A, Kitajima T, Shimura T, Kawamura M, Matsushita K, Okugawa Y, Amano K, Otake K, Okita Y, Ohi M, Inoue M, Uchida K, Hirayama M, Toiyama Y., Oncol Lett. April 1, 2022; 23 (4): 136.

Comprehensive Analysis of the Oncogenic Role of Targeting Protein for Xklp2 (TPX2) in Human Malignancies., Shao T, Jiang X, Bao G, Li C, Guo C., Dis Markers. January 1, 2022; 2022 7571066.

The Cytoskeleton and Its Roles in Self-Organization Phenomena: Insights from Xenopus Egg Extracts., Geisterfer ZM, Guilloux G, Gatlin JC, Gatlin JC, Gibeaux R., Cells. August 26, 2021; 10 (9):         

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry., Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L., Nat Commun. March 26, 2021; 12 (1): 1899.                  

High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability., Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT., BMC Cancer. February 23, 2021; 21 (1): 186.

Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis., Li Y, Li J, Shen Y, Xiong Y, Li X, Qin Z., Aquat Toxicol. January 21, 2021; 232 105760.      

Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer., Zhu H, Liu J, Feng J, Zhang Q, Bian T, Li X, Sun H, Zhang J, Liu Y., Medicine (Baltimore). December 4, 2020; 99 (49): e23554.            

CircPOSTN/miR-361-5p/TPX2 axis regulates cell growth, apoptosis and aerobic glycolysis in glioma cells., Long N, Chu L, Jia J, Peng S, Gao Y, Yang H, Yang Y, Zhao Y, Liu J., Cancer Cell Int. August 6, 2020; 20 374.                  

The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation., Wang Y, Wang H, Yan Z, Li G, Hu G, Zhang H, Huang D, Wang Y, Zhang X, Yan Y, Lu Q, Cheng M, Luo S., Cell Commun Signal. July 28, 2020; 18 (1): 116.              

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin., Douglas P, Ye R, Radhamani S, Cobban A, Jenkins NP, Bartlett E, Roveredo J, Kettenbach AN, Lees-Miller SP., Mol Cell Biol. June 15, 2020; 40 (13):                   

The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy., Thawani A, Rale MJ, Coudray N, Bhabha G, Stone HA, Shaevitz JW, Petry S., Elife. June 15, 2020; 9                           

Cell Biology: Tubulin Contributes to Spindle Size Scaling., Levy DL., Curr Biol. June 8, 2020; 30 (11): R637-R639.  

Tumor-Suppressive MicroRNA-216b Binds to TPX2, Activating the p53 Signaling in Human Cutaneous Squamous Cell Carcinoma., Feng C, Zhang HL, Zeng A, Bai M, Wang XJ., Mol Ther Nucleic Acids. June 5, 2020; 20 186-195.            

Cell division cycle proteinising prognostic biomarker of breast cancer., Cheng L, Huang YZ, Chen WX, Shi L, Li Z, Zhang X, Dai XY, Wei JF, Ding Q., Biosci Rep. May 29, 2020; 40 (5):


Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4., Yang C, Shen S, Zheng X, Ye K, Ge H, Sun Y, Lu Y., FASEB J. May 1, 2020; 34 (5): 6055-6069.

Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma., Ding X, Huang T, Peng C, Ahn KS, Andersen JB, Lewinska M, Cao Y, Xu G, Chen G, Kong B, Friess H, Shen S, Roberts LR, Wang L, Zou X., J Cancer. February 3, 2020; 11 (8): 2241-2251.              

Biochemical reconstitution of branching microtubule nucleation., Alfaro-Aco R, Thawani A, Petry S., Elife. January 14, 2020; 9                                   

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation., King MR, Petry S., Nat Commun. January 14, 2020; 11 (1): 270.                            

Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma., Ji Y, Yin Y, Zhang W., Int J Genomics. January 1, 2020; 2020 2061024.              

Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2., Levine TP., F1000Res. January 1, 2020; 9 1052.          

TPX2 as a Novel Prognostic Indicator and Promising Therapeutic Target in Triple-negative Breast Cancer., Jiang Y, Liu Y, Tan X, Yu S, Luo J., Clin Breast Cancer. December 1, 2019; 19 (6): 450-455.

TPX2 silencing exerts anti‑tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway., Huang DH, Jian J, Li S, Zhang Y, Liu LZ., Int J Mol Med. December 1, 2019; 44 (6): 2113-2122.          

HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer., Li F, Su M, Zhao H, Xie W, Cao S, Xu Y, Xu Y, Chen W, Wang L, Hou L, Tan W., Am J Transl Res. November 15, 2019; 11 (11): 7035-7048.

Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri., Miller KE, Session AM, Heald R., Curr Biol. November 4, 2019; 29 (21): 3720-3727.e5.                  

Prognostic significance of TPX2 and NIBP in esophageal cancer., Sui C, Song Z, Yu H, Wang H., Oncol Lett. October 1, 2019; 18 (4): 4221-4229.      

The clinical significance and prognostic value of Xenopus kinesin-like protein 2 expressions in human tumors: A systematic review and meta-analysis., Yang W, Wan H, Shan R, Wen W, Li J, Luo D, Wan RH., J Cell Physiol. September 1, 2019; 234 (9): 14991-14998.

Spatiotemporal organization of branched microtubule networks., Thawani A, Stone HA, Shaevitz JW, Petry S., Elife. May 8, 2019; 8                   

Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling., Brownlee C, Heald R., Cell. February 7, 2019; 176 (4): 805-815.e8.                  

Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer., Chen M, Zhang H, Zhang G, Zhong A, Ma Q, Kai J, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R., Biochem Biophys Res Commun. December 9, 2018; 507 (1-4): 74-82.          

TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT., Zou Z, Zheng B, Li J, Lv X, Zhang H, Yu F, Kong L, Li Y, Yu M, Fang L, Liang B., Biomed Pharmacother. November 1, 2018; 107 1286-1293.

Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis., Liu W, Xu J, Zhang C., Medicine (Baltimore). November 1, 2018; 97 (46): e13303.          

Dissecting Protein Complexes in Branching Microtubule Nucleation Using Meiotic Xenopus Egg Extracts., Song JG, Petry S., Cold Spring Harb Protoc. September 4, 2018; 2018 (9):


Overexpression of TPX2 is associated with progression and prognosis of prostate cancer., Zou J, Huang RY, Jiang FN, Chen DX, Wang C, Han ZD, Liang YX, Zhong WD., Oncol Lett. September 1, 2018; 16 (3): 2823-2832.            

Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules., Song JG, King MR, Zhang R, Kadzik RS, Thawani A, Petry S., J Cell Biol. July 2, 2018; 217 (7): 2417-2428.          

Subcellular scaling: does size matter for cell division?, Heald R, Gibeaux R., Curr Opin Cell Biol. June 1, 2018; 52 88-95.

Spindle assembly in egg extracts of the Marsabit clawed frog, Xenopus borealis., Kitaoka M, Heald R, Gibeaux R., Cytoskeleton (Hoboken). June 1, 2018; 75 (6): 244-257.

Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis., Wang G, Wang Q, Li Z, Liu C, He X., Onco Targets Ther. March 5, 2018; 11 1229-1243.            

TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer., Yan L, Li Q, Yang J, Qiao B., J Cell Biochem. February 1, 2018; 119 (2): 1791-1803.

MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2., Chen H, Liu L, Li X, Shi Y, Liu N., Am J Cancer Res. February 1, 2018; 8 (2): 291-301.

Aurora A activation in mitosis promoted by BuGZ., Huang Y, Li T, Ems-McClung SC, Walczak CE, Prigent C, Zhu X, Zhang X, Zheng Y., J Cell Biol. January 2, 2018; 217 (1): 107-116.                

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