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Summary Expression Phenotypes Gene Literature (190) GO Terms (26) Nucleotides (140) Proteins (57) Interactants (149) Wiki
XB-GENEPAGE-5921461

Papers associated with kcnq1



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Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants., Rinné S, Oertli A, Nagel C, Tomsits P, Jenewein T, Kääb S, Kauferstein S, Loewe A, Beckmann BM, Decher N., Int J Mol Sci. January 10, 2023; 24 (2):                       

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex., Kasuya G, Nakajo K., Elife. November 4, 2022; 11               

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277., Willegems K, Eldstrom J, Kyriakis E, Ataei F, Sahakyan H, Dou Y, Russo S, Van Petegem F, Fedida D., Nat Commun. June 29, 2022; 13 (1): 3760.

Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels., Edmond MA, Hinojo-Perez A, Wu X, Perez Rodriguez ME, Barro-Soria R., Elife. June 1, 2022; 11                           

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels., Zou X, Wu X, Sampson KJ, Colecraft HM, Larsson HP, Kass RS., Front Physiol. January 1, 2022; 13 902224.                      

Virus-Host Interactions of Enteroviruses and Parvovirus B19 in Myocarditis., Ho HT, Peischard S, Strutz-Seebohm N, Seebohm G., Cell Physiol Biochem. November 18, 2021; 55 (6): 679-703.        

The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., Manville RW, Abbott GW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.

Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1., Yazdi S, Nikesjö J, Miranda W, Corradi V, Tieleman DP, Noskov SY, Larsson HP, Liin SI., J Gen Physiol. June 7, 2021; 153 (6):


Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects., Lin Y, Grinter SZ, Lu Z, Xu X, Wang HZ, Liang H, Hou P, Gao J, Clausen C, Shi J, Zhao W, Ma Z, Liu Y, White KM, Zhao L, Kang PW, Zhang G, Cohen IS, Zou X, Cui J., Proc Natl Acad Sci U S A. May 18, 2021; 118 (20):


Compound Heterozygous KCNQ1 Mutations Causing Recessive Romano-Ward Syndrome: Functional Characterization by Mutant Co-expression., González-Garrido A, Domínguez-Pérez M, Jacobo-Albavera L, López-Ramírez O, Guevara-Chávez JG, Zepeda-García O, Iturralde P, Carnevale A, Villarreal-Molina T., Front Cardiovasc Med. February 22, 2021; 8 625449.

Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness., Oertli A, Rinné S, Moss R, Kääb S, Seemann G, Beckmann BM, Decher N., Int J Mol Sci. January 23, 2021; 22 (3):             

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics., Abbott GW, Redford KE, Yoshimura RF, Manville RW, Moreira L, Tran K, Arena G, Kookootsedes A, Lasky E, Gunnison E., Front Physiol. January 1, 2021; 12 777057.

Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I., Maghera J, Li J, Lamothe SM, Braun M, Appendino JP, Au PYB, Kurata HT., Epilepsia Open. December 1, 2020; 5 (4): 562-573.          

In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders., Grupe M, Bentzen BH, Benned-Jensen T, Nielsen V, Frederiksen K, Jensen HS, Jacobsen AM, Skibsbye L, Sams AG, Grunnet M, Rottländer M, Bastlund JF., Eur J Pharmacol. November 15, 2020; 887 173440.

Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo., Skarsfeldt MA, Liin SI, Larsson HP, Bentzen BH., Acta Physiol (Oxf). August 1, 2020; 229 (4): e13471.

A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation., Liu Y, Xu X, Gao J, Naffaa MM, Liang H, Shi J, Wang HZ, Yang ND, Hou P, Zhao W, White KM, Kong W, Dou A, Cui A, Zhang G, Cohen IS, Zou X, Cui J., Commun Biol. July 16, 2020; 3 (1): 385.

The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator., Redford KE, Abbott GW., Commun Biol. July 8, 2020; 3 (1): 356.

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity., Lübke M, Schreiber JA, Le Quoc T, Körber F, Müller J, Sivanathan S, Matschke V, Schubert J, Strutz-Seebohm N, Seebohm G, Scherkenbeck J., ChemMedChem. June 17, 2020; 15 (12): 1078-1088.

4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region., Bollmann E, Schreiber JA, Ritter N, Peischard S, Ho HT, Wünsch B, Strünker T, Meuth S, Budde T, Strutz-Seebohm N, Seebohm G., Cell Physiol Biochem. April 8, 2020; 54 (2): 321-332.

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state., Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR., Elife. February 25, 2020; 9                                     

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant., Manville RW, Abbott GW., FASEB J. October 1, 2019; 33 (10): 11349-11363.

KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity., Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW., J Cell Physiol. August 1, 2019; 234 (8): 13361-13369.

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling., Hou P, Shi J, White KM, Gao Y, Cui J., Elife. July 22, 2019; 8                     

Probing the Dynamics and Structural Topology of the Reconstituted Human KCNQ1 Voltage Sensor Domain (Q1-VSD) in Lipid Bilayers Using Electron Paramagnetic Resonance Spectroscopy., Dixit G, Sahu ID, Reynolds WD, Wadsworth TM, Harding BD, Jaycox CK, Dabney-Smith C, Sanders CR, Lorigan GA., Biochemistry. February 19, 2019; 58 (7): 965-973.

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner., Manville RW, Abbott GW., Commun Biol. January 1, 2019; 2 401.                    

Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation., De Silva AM, Manville RW, Abbott GW., Sci Adv. November 14, 2018; 4 (11): eaav0824.            

Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels., Manville RW, Abbott GW., Mol Pharmacol. October 1, 2018; 94 (4): 1155-1163.

Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket., Manville RW, Abbott GW., Nat Commun. September 21, 2018; 9 (1): 3845.                  

Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results., Chua HC, Servatius H, Asatryan B, Schaller A, Rieubland C, Noti F, Seiler J, Roten L, Baldinger SH, Tanner H, Fuhrer J, Haeberlin A, Lam A, Pless SA, Medeiros-Domingo A., Clin Res Cardiol. August 1, 2018; 107 (8): 670-678.

Direct neurotransmitter activation of voltage-gated potassium channels., Manville RW, Papanikolaou M, Abbott GW., Nat Commun. May 10, 2018; 9 (1): 1847.            

A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity., Liu Z, Bartels P, Sadeghi M, Du T, Dai Q, Zhu C, Yu S, Wang S, Dong M, Sun T, Guo J, Peng S, Jiang L, Adams DJ, Dai Q., Sci Rep. January 17, 2018; 8 (1): 1004.                

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening., Hou P, Eldstrom J, Shi J, Zhong L, McFarland K, Gao Y, Fedida D, Cui J., Nat Commun. November 23, 2017; 8 (1): 1730.                            

PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels., Kim RY, Pless SA, Kurata HT., Proc Natl Acad Sci U S A. November 7, 2017; 114 (45): E9702-E9711.                

Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression., Wu M, Obara Y, Ohshima S, Nagasawa Y, Ishii K., Biochem Biophys Res Commun. November 4, 2017; 493 (1): 409-415.

Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling., Lee HC, Lee HC, Rudy Y, Liang H, Chen CC, Luo CH, Sheu SH, Cui J., J Med Biol Eng. October 1, 2017; 37 (5): 780-789.          

KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions., Barro-Soria R, Ramentol R, Liin SI, Perez ME, Kass RS, Larsson HP., Proc Natl Acad Sci U S A. August 29, 2017; 114 (35): E7367-E7376.

Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium., Pedersen PJ, Thomsen KB, Flak JB, Tejada MA, Hauser F, Trachsel D, Buhl R, Kalbfleisch T, DePriest MS, MacLeod JN, Calloe K, Klaerke DA., Res Vet Sci. August 1, 2017; 113 79-86.

Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome., Sun J, MacKinnon R., Cell. June 1, 2017; 169 (6): 1042-1050.e9.

Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations., Peng G, Barro-Soria R, Sampson KJ, Larsson HP, Kass RS., Sci Rep. April 6, 2017; 7 45911.                

Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4., Abbott GW., FASEB J. August 1, 2016; 30 (8): 2959-69.

Bioelectric signalling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome., Adams DS, Uzel SG, Akagi J, Wlodkowic D, Andreeva V, Yelick PC, Devitt-Lee A, Pare JF, Levin M., J Physiol. June 15, 2016; 594 (12): 3245-70.                              

Iron Overload Leading to Torsades de Pointes in β-Thalassemia and Long QT Syndrome., Refaat MM, El Hage L, Steffensen AB, Hotait M, Schmitt N, Scheinman M, Badhwar N., Card Electrophysiol Clin. March 1, 2016; 8 (1): 247-56.

The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols., Xie C, Liu HW, Pan N, Ding JP, Yao J., Acta Pharmacol Sin. January 1, 2016; 37 (1): 124-33.          

KCNE3 acts by promoting voltage sensor activation in KCNQ1., Barro-Soria R, Perez ME, Larsson HP., Proc Natl Acad Sci U S A. December 29, 2015; 112 (52): E7286-92.

High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB, Refaat MM, David JP, Mujezinovic A, Calloe K, Wojciak J, Nussbaum RL, Scheinman MM, Schmitt N., Sci Rep. January 12, 2015; 5 10009.              

An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels., Inanobe A, Tsuzuki C, Kurachi Y., Cell Physiol Biochem. January 1, 2015; 36 (5): 1847-61.

SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels., Elvira B, Warsi J, Fezai M, Munoz C, Lang F., Cell Physiol Biochem. January 1, 2015; 37 (5): 2032-42.

Regulation of Voltage Gated K+ Channel KCNE1/KCNQ1 by the Janus Kinase JAK3., Warsi J, Abousaab A, Fezai M, Elvira B, Lang F., Cell Physiol Biochem. January 1, 2015; 37 (6): 2476-85.

Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites., Choi SH, Lee BH, Kim HJ, Jung SW, Kim HS, Shin HC, Lee JH, Kim HC, Rhim H, Hwang SH, Ha TS, Kim HJ, Cho H, Nah SY., Mol Cells. September 1, 2014; 37 (9): 656-63.                

Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1., Wu M, Obara Y, Norota I, Nagasawa Y, Ishii K., Pflugers Arch. May 1, 2014; 466 (5): 937-46.

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