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Summary Expression Phenotypes Gene Literature (14) GO Terms (21) Nucleotides (102) Proteins (37) Interactants (278) Wiki

Papers associated with lgr4

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Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd., Lee H, Lee H, Sun R, Niehrs C., J Biol Chem. February 1, 2022; 298 (2): 101586.                

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification., Reis AH, Sokol SY., Sci Rep. June 28, 2021; 11 (1): 13433.            

R-spondins are BMP receptor antagonists in Xenopus early embryonic development., Lee H, Lee H, Seidl C, Sun R, Glinka A, Niehrs C., Nat Commun. November 4, 2020; 11 (1): 5570.                                            

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6., Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Vleminckx K, Barker N, Kayserili H, Reversade B., Nature. May 1, 2018; 557 (7706): 564-569.  

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover., Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C., Dev Cell. October 9, 2017; 43 (1): 71-82.e6.                                

High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis., Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T., Dev Biol. June 15, 2017; 426 (2): 270-290.                  

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength., de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.          

Syndecan-4 inhibits Wnt/β-catenin signaling through regulation of low-density-lipoprotein receptor-related protein (LRP6) and R-spondin 3., Astudillo P, Carrasco H, Larraín J., Int J Biochem Cell Biol. January 1, 2014; 46 103-12.            

Crystal structures of Lgr4 and its complex with R-spondin1., Xu K, Xu Y, Xu Y, Rajashankar KR, Robev D, Nikolov DB., Structure. September 3, 2013; 21 (9): 1683-9.

Multi-functional norrin is a ligand for the LGR4 receptor., Deng C, Reddy P, Cheng Y, Luo CW, Hsiao CL, Hsueh AJ., J Cell Sci. May 1, 2013; 126 (Pt 9): 2060-8.

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin., Zebisch M, Xu Y, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY., Nat Commun. January 1, 2013; 4 2787.              

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner., Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F., Nature. April 29, 2012; 485 (7397): 195-200.

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling., Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C., EMBO Rep. September 30, 2011; 12 (10): 1055-61.

Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis., Sun G, Hasebe T, Fujimoto K, Lu R, Fu L, Matsuda H, Kajita M, Ishizuya-Oka A, Shi YB., PLoS One. October 22, 2010; 5 (10): e13605.                    

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