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Summary Expression Phenotypes Gene Literature (34) GO Terms (0) Nucleotides (74) Proteins (36) Interactants (151) Wiki
XB-GENEPAGE-6447551

Papers associated with scn2a



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A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities., Kearney JA, Plummer NW, Smith MR, Kapur J, Cummins TR, Waxman SG, Goldin AL, Meisler MH., Neuroscience. January 1, 2001; 102 (2): 307-17.

The pentapeptide QYNAD does not block voltage-gated sodium channels., Cummins TR, Renganathan M, Stys PK, Herzog RI, Scarfo K, Horn R, Dib-Hajj SD, Waxman SG., Neurology. January 28, 2003; 60 (2): 224-9.

Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current., Macdonald RL, Bianchi MT, Bianch MT, Feng H., Exp Neurol. November 1, 2003; 184 Suppl 1 S58-67.

Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit., Qin N, D'Andrea MR, Lubin ML, Shafaee N, Codd EE, Correa AM., Eur J Biochem. December 1, 2003; 270 (23): 4762-70.

OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels., Jalali A, Bosmans F, Amininasab M, Clynen E, Cuypers E, Zaremirakabadi A, Sarbolouki MN, Schoofs L, Vatanpour H, Tytgat J., FEBS Lett. August 1, 2005; 579 (19): 4181-6.

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes., Bosmans F, Rash L, Zhu S, Diochot S, Lazdunski M, Escoubas P, Tytgat J., Mol Pharmacol. February 1, 2006; 69 (2): 419-29.

RE-1 silencer of transcription/neural restrictive silencer factor modulates ectodermal patterning during Xenopus development., Olguín P, Oteíza P, Gamboa E, Gómez-Skármeta JL, Kukuljan M., J Neurosci. March 8, 2006; 26 (10): 2820-9.                    

An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability., Barela AJ, Waddy SP, Lickfett JG, Hunter J, Anido A, Helmers SL, Goldin AL, Escayg A., J Neurosci. March 8, 2006; 26 (10): 2714-23.

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels., Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, Bulaj G., J Biol Chem. October 19, 2007; 282 (42): 30699-706.

Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated Na+ channel regulation., Lee JH, Lee BH, Choi SH, Yoon IS, Shin TJ, Pyo MK, Lee SM, Kim HC, Nah SY., Brain Res. April 8, 2008; 1203 61-7.

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7., Fiedler B, Zhang MM, Buczek O, Azam L, Bulaj G, Norton RS, Olivera BM, Yoshikami D., Biochem Pharmacol. June 15, 2008; 75 (12): 2334-44.

Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin., Tan J, Soderlund DM., Neurotoxicology. January 1, 2009; 30 (1): 81-9.

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels., Zhang MM, McArthur JR, Azam L, Bulaj G, Olivera BM, French RJ, Yoshikami D., Channels (Austin). January 1, 2009; 3 (1): 32-8.

Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes., Peng F, Mellor IR, Williamson MS, Davies TG, Field LM, Usherwood PN., Neurotoxicology. May 1, 2009; 30 (3): 358-67.

The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel., Yang YC, Hsieh JY, Kuo CC., J Gen Physiol. August 1, 2009; 134 (2): 95-113.                      

Induction of vertebrate regeneration by a transient sodium current., Tseng AS, Beane WS, Lemire JM, Masi A, Levin M., J Neurosci. September 29, 2010; 30 (39): 13192-200.                    

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics., Arcisio-Miranda M, Muroi Y, Chowdhury S, Chanda B., J Gen Physiol. November 1, 2010; 136 (5): 541-54.                

Localization of receptor site on insect sodium channel for depressant β-toxin BmK IT2., He H, Liu Z, Dong B, Zhang J, Shu X, Zhou J, Ji Y., PLoS One. January 7, 2011; 6 (1): e14510.            

A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors., Favreau P, Benoit E, Hocking HG, Carlier L, D' hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J., Br J Pharmacol. July 1, 2012; 166 (5): 1654-68.

De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy., Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R., Nat Genet. November 1, 2012; 44 (11): 1255-9.

Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues., Walewska A, Han TS, Zhang MM, Yoshikami D, Bulaj G, Rolka K., Eur J Med Chem. July 1, 2013; 65 144-50.

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models., Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, King GF., Proc Natl Acad Sci U S A. October 22, 2013; 110 (43): 17534-9.

Crystallographic insights into sodium-channel modulation by the β4 subunit., Gilchrist J, Das S, Van Petegem F, Bosmans F., Proc Natl Acad Sci U S A. December 17, 2013; 110 (51): E5016-24.

The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes., Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Sata T., Anesth Analg. March 1, 2014; 118 (3): 554-62.

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain., Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN., Curr Biol. March 3, 2014; 24 (5): 473-83.

Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes., Lee JH, Liu J, Shin M, Hong M, Nah SY, Bae H., Acta Pharmacol Sin. July 1, 2014; 35 (7): 862-8.        

Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 expressed in xenopus oocytes., Horishita T, Yanagihara N, Ueno S, Sudo Y, Uezono Y, Okura D, Minami T, Kawasaki T, Sata T., Anesthesiology. September 1, 2014; 121 (3): 620-31.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. January 12, 2015; 5 14763.                                

Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy., Corbett MA, Bellows ST, Li M, Carroll R, Micallef S, Carvill GL, Myers CT, Howell KB, Maljevic S, Lerche H, Gazina EV, Mefford HC, Bahlo M, Berkovic SF, Petrou S, Scheffer IE, Gecz J., Neurology. November 8, 2016; 87 (19): 1975-1984.

Anesthetic-sensitive ion channel modulation is associated with a molar water solubility cut-off., Brosnan RJ, Pham TL., BMC Pharmacol Toxicol. September 14, 2018; 19 (1): 57.                

Genomic Takeover by Transposable Elements in the Strawberry Poison Frog., Rogers RL, Zhou L, Chu C, Márquez R, Corl A, Linderoth T, Freeborn L, MacManes MD, Xiong Z, Zheng J, Guo C, Xun X, Kronforst MR, Summers K, Wu Y, Yang H, Richards-Zawacki CL, Zhang G, Nielsen R., Mol Biol Evol. December 1, 2018; 35 (12): 2913-2927.              

Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations., Mason ER, Wu F, Patel RR, Xiao Y, Cannon SC, Cummins TR., eNeuro. October 16, 2019; 6 (5):                   

Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience., Willsey HR, Exner CRT, Xu Y, Xu Y, Everitt A, Sun N, Wang B, Dea J, Schmunk G, Zaltsman Y, Teerikorpi N, Kim A, Anderson AS, Shin D, Seyler M, Nowakowski TJ, Harland RM, Willsey AJ, State MW., Neuron. March 3, 2021; 109 (5): 788-804.e8.

A convergent molecular network underlying autism and congenital heart disease., Rosenthal SB, Willsey HR, Xu Y, Xu Y, Mei Y, Dea J, Wang S, Curtis C, Sempou E, Khokha MK, Chi NC, Willsey AJ, Fisch KM, Ideker T., Cell Syst. November 17, 2021; 12 (11): 1094-1107.e6.            

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