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Summary Expression Phenotypes Gene Literature (134) GO Terms (14) Nucleotides (338) Proteins (73) Interactants (468) Wiki
XB-GENEPAGE-950934

Papers associated with pam



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Coffee and cigarettes: Modulation of high and low sensitivity α4β2 nicotinic acetylcholine receptors by n-MP, a biomarker of coffee consumption., Papke RL, Karaffa M, Horenstein NA, Stokes C., Neuropharmacology. September 15, 2022; 216 109173.


Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas., Zhong G, Ahimaz P, Edwards NA, Hagen JJ, Faure C, Lu Q, Kingma P, Middlesworth W, Khlevner J, El Fiky M, Schindel D, Fialkowski E, Kashyap A, Forlenza S, Kenny AP, Zorn AM, Shen Y, Chung WK., HGG Adv. July 14, 2022; 3 (3): 100107.        


Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis., Shi Z, Jiang H, Liu G, Shi S, Zhang X, Chen Y., Cell Biosci. July 8, 2022; 12 (1): 104.                                


Optimization of CRISPR/Cas9-mediated gene disruption in Xenopus laevis using a phenotypic image analysis technique., Tanouchi M, Igawa T, Suzuki N, Suzuki M, Hossain N, Ochi H, Ogino H., Dev Growth Differ. May 1, 2022; 64 (4): 219-225.                


Xenopus laevis il11ra.L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration., Suzuki S, Sasaki K, Fukazawa T, Kubo T, Kubo T., Sci Rep. February 3, 2022; 12 (1): 1903.                      


Targeted search for scaling genes reveals matrixmetalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos., Orlov EE, Nesterenko AM, Korotkova DD, Parshina EA, Martynova NY, Zaraisky AG., Dev Cell. January 10, 2022; 57 (1): 95-111.e12.                                


Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis., Jönsson ÅLM, Hernando N, Knöpfel T, Mogensen S, Bendstrup E, Hilberg O, Christensen JH, Simonsen U, Wagner CA., Hum Genomics. January 1, 2022; 16 (1): 13.


Functions of block of proliferation 1 during anterior development in Xenopus laevis., Gärtner C, Meßmer A, Dietmann P, Kühl M, Kühl SJ., PLoS One. January 1, 2022; 17 (8): e0273507.                        


Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease., Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS., Proc Natl Acad Sci U S A. September 28, 2021; 118 (39):                                                   


Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation., Fukunaga K, Tanji M, Hanzawa N, Kuroda H, Inui M., Biochem Biophys Rep. September 1, 2021; 27 101047.          


Stable desensitization of α7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site., Pismataro MC, Horenstein NA, Stokes C, Dallanoce C, Thakur GA, Papke RL., Eur J Pharmacol. August 15, 2021; 905 174179.


The molecular basis of coupling between poly(A)-tail length and translational efficiency., Xiang K, Bartel DP., Elife. July 2, 2021; 10                       


Desformylflustrabromine (dFBr), a positive allosteric modulator of the α4β2 nicotinic receptor modulates the hypnotic response to ethanol., DeCristofano L, Decker S, Schulte MK, Suryanarayanan A., Alcohol. June 1, 2021; 93 35-44.


Genome Evolutionary Dynamics Meets Functional Genomics: A Case Story on the Identification of SLC25A44., Darbani B., Int J Mol Sci. May 26, 2021; 22 (11):             


Rab11fip5 regulates telencephalon development via ephrinB1 recycling., Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO., Development. February 2, 2021; 148 (3):                                                             


Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway., Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Muñoz N, Albrecht LV, Sosa EA, Wohlschlegel JA, De Robertis EM., Sci Rep. December 9, 2020; 10 (1): 21555.            


A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors., Sheipouri D, Gallagher CI, Shimmon S, Rawling T, Vandenberg RJ., Biomolecules. November 30, 2020; 10 (12):                                                     


CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis., Wiechmann AF, Martin TA, Horb ME., Sci Rep. August 13, 2020; 10 (1): 13757.                                  


Functional analysis of the OsNPF4.5 nitrate transporter reveals a conserved mycorrhizal pathway of nitrogen acquisition in plants., Wang S, Chen A, Xie K, Yang X, Luo Z, Chen J, Zeng D, Ren Y, Yang C, Wang L, Feng H, López-Arredondo DL, Herrera-Estrella LR, Xu G., Proc Natl Acad Sci U S A. July 14, 2020; 117 (28): 16649-16659.            


Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription., Oikawa M, Simeone A, Hormanseder E, Teperek M, Gaggioli V, O'Doherty A, Falk E, Sporniak M, D'Santos C, Franklin VNR, Kishore K, Bradshaw CR, Keane D, Freour T, David L, Grzybowski AT, Ruthenburg AJ, Gurdon J, Jullien J., Nat Commun. July 13, 2020; 11 (1): 3491.              


The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos., Willsey HR, Xu Y, Xu Y, Everitt A, Dea J, Exner CRT, Willsey AJ, State MW, Harland RM., Development. June 22, 2020; 147 (21):                             


All-fibre supercontinuum laser for in vivo multispectral photoacoustic microscopy of lipids in the extended near-infrared region., Dasa MK, Nteroli G, Bowen P, Messa G, Feng Y, Petersen CR, Koutsikou S, Bondu M, Moselund PM, Podoleanu A, Bradu A, Markos C, Bang O., Photoacoustics. June 1, 2020; 18 100163.            


Modeling ocular lens disease in Xenopus., Viet J, Reboutier D, Hardy S, Lachke SA, Paillard L, Gautier-Courteille C., Dev Dyn. May 1, 2020; 249 (5): 610-621.          


Characterization of AN6001, a positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors., van Hout M, Klein J, Ahring PK, Brown DT, Thaneshwaran S, Dos Santos AB, Jensen AA, Kohlmeier KA, Christophersen P, Dyhring T., Biochem Pharmacol. April 1, 2020; 174 113788.


The AP-1 transcription factor JunB functions in Xenopus tail regeneration by positively regulating cell proliferation., Nakamura M, Yoshida H, Takahashi E, Wlizla M, Takebayashi-Suzuki K, Horb ME, Suzuki A, Suzuki A., Biochem Biophys Res Commun. February 19, 2020; 522 (4): 990-995.              


An Orphan Pheromone Receptor Affects the Mating Behavior of Helicoverpa armigera., Cao S, Huang T, Shen J, Liu Y, Wang G., Front Physiol. January 1, 2020; 11 413.        


Flavonoids as positive allosteric modulators of α7 nicotinic receptors., Nielsen BE, Bermudez I, Bouzat C., Neuropharmacology. December 1, 2019; 160 107794.


Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation., Xue Y, He X, Yang T, Wang Y, Liu Z, Zhang G, Wang Y, Wang K, Zhang L, Zhang L., Eur J Med Chem. November 15, 2019; 182 111618.


NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress., Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C., Elife. September 30, 2019; 8                                     


Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC., Norleans J, Wang J, Kuryatov A, Leffler A, Doebelin C, Kamenecka TM, Lindstrom J., J Biol Chem. August 9, 2019; 294 (32): 12132-12145.


Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs., Li X, Xie W, Wang X, Huang Z, Bian X, Wang K, Sun Q., Bioorg Med Chem Lett. August 1, 2019; 29 (15): 1928-1933.


Disruption of an amino acid transporter LHT1 leads to growth inhibition and low yields in rice., Wang X, Yang G, Shi M, Hao D, Wei Q, Wang Z, Fu S, Su Y, Xia J., BMC Plant Biol. June 20, 2019; 19 (1): 268.          


Heteromeric neuronal nicotinic acetylcholine receptors with mutant beta subunits acquire sensitivity to α7-selective positive allosteric modulators., Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL., J Pharmacol Exp Ther. June 7, 2019;


Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model., Sun LL, Yang TY, Wei NN, Lu W, Jiao WX, Zhou QQ, Miao YZ, Gao Q, Wang XT, Sun Q, Wang K., Acta Pharmacol Sin. June 1, 2019; 40 (6): 737-745.


Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site., Gulsevin A, Papke RL, Stokes C, Garai S, Thakur GA, Quadri M, Horenstein NA., Mol Pharmacol. June 1, 2019; 95 (6): 606-614.


Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1., Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L, Ryneš J, Dave Z, Fernández-Llamazares AI, Vácha R, Tripsianes K, Hoffmann C, Bryja V., Nat Commun. April 18, 2019; 10 (1): 1804.                  


Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors., Choudhary S, Marjianović DS, Wong CR, Zhang X, Abongwa M, Coats JR, Trailović SM, Martin RJ, Robertson AP., Int J Parasitol Drugs Drug Resist. April 1, 2019; 9 44-53.                


Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice., Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X, Huang Z, Meng Y, Luo L, Wang X, Bian X, Zhang F, Wang K, Sun Q., J Med Chem. January 10, 2019; 62 (1): 159-173.


Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107., Quadri M, Garai S, Thakur GA, Stokes C, Gulsevin A, Horenstein NA, Papke RL., Mol Pharmacol. January 1, 2019; 95 (1): 43-61.


The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators., Sapkota K, Dore K, Tang K, Irvine M, Fang G, Burnell ES, Malinow R, Jane DE, Monaghan DT., Biochem Pharmacol. January 1, 2019; 159 140-153.


des-Formylflustrabromine (dFBr): A Structure-Activity Study on Its Ability To Potentiate the Action of Acetylcholine at α4β2 Nicotinic Acetylcholine Receptors., Dukat M, Jain A, German N, Ferrara-Pontoriero R, Huang Y, Ma Y, Schulte MK, Glennon RA., ACS Chem Neurosci. December 19, 2018; 9 (12): 2984-2996.


B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation., Garai S, Raja KS, Papke RL, Deschamps JR, Damaj MI, Thakur GA., ACS Med Chem Lett. November 8, 2018; 9 (11): 1144-1148.


The Antinociceptive and Anti-Inflammatory Properties of the α7 nAChR Weak Partial Agonist p-CF3N,N-diethyl-N''-phenylpiperazine., Quadri M, Bagdas D, Toma W, Stokes C, Horenstein NA, Damaj MI, Papke RL., J Pharmacol Exp Ther. November 1, 2018; 367 (2): 203-214.


Molecular function of the novel α7β2 nicotinic receptor., Nielsen BE, Minguez T, Bermudez I, Bouzat C., Cell Mol Life Sci. July 1, 2018; 75 (13): 2457-2471.


CRISPR/Cas9-mediated efficient and precise targeted integration of donor DNA harboring double cleavage sites in Xenopus tropicalis., Mao CZ, Zheng L, Zhou YM, Wu HY, Xia JB, Liang CQ, Guo XF, Peng WT, Zhao H, Cai WB, Kim SK, Park KS, Cai DQ, Qi XF., FASEB J. June 13, 2018; fj201800093.              


Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states., Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, Bagdas D, Kulkarni AR, Horenstein NA., Br J Pharmacol. June 1, 2018; 175 (11): 1838-1854.


Cerebellar α6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders., Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T., Br J Pharmacol. June 1, 2018; 175 (12): 2414-2427.


The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture., Takahashi C, Miyatake K, Kusakabe M, Nishida E., J Biol Chem. June 1, 2018; 293 (22): 8342-8361.                                      


An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups., Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF., Elife. May 24, 2018; 7                                                                         


Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors., Olander ER, Madjroh N, Bunch L, Söderhielm PC, Jensen AA., Biochem Pharmacol. April 1, 2018; 150 305-319.

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