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Summary Expression Phenotypes Gene Literature (95) GO Terms (0) Nucleotides (11) Proteins (11) Interactants (134) Wiki
XB-GENEPAGE-959133

Papers associated with kcnj6



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Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain., Bond CT, Ammälä C, Ashfield R, Blair TA, Gribble F, Khan RN, Lee K, Proks P, Rowe IC, Sakura H., FEBS Lett. June 19, 1995; 367 (1): 61-6.

Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers., Kofuji P, Davidson N, Lester HA., Proc Natl Acad Sci U S A. July 3, 1995; 92 (14): 6542-6.

Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers., Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J., Biochem Biophys Res Commun. July 17, 1995; 212 (2): 657-63.

Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels., Ferrer J, Nichols CG, Makhina EN, Salkoff L, Bernstein J, Gerhard D, Wasson J, Ramanadham S, Permutt A., J Biol Chem. November 3, 1995; 270 (44): 26086-91.

Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels., Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M., J Biol Chem. December 1, 1995; 270 (48): 28660-7.

Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end., Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M., FEBS Lett. January 2, 1996; 378 (1): 64-8.

A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes., Isomoto S, Kondo C, Takahashi N, Matsumoto S, Yamada M, Takumi T, Horio Y, Kurachi Y., Biochem Biophys Res Commun. January 5, 1996; 218 (1): 286-91.

The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel., Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE., FEBS Lett. January 22, 1996; 379 (1): 31-7.

Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels., Slesinger PA, Patil N, Liao YJ, Jan YN, Jan LY, Cox DR., Neuron. February 1, 1996; 16 (2): 321-31.

Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells., Kofuji P, Hofer M, Millen KJ, Millonig JH, Davidson N, Lester HA, Hatten ME., Neuron. May 1, 1996; 16 (5): 941-52.

The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2., Tong Y, Wei J, Zhang S, Strong JA, Dlouhy SR, Hodes ME, Ghetti B, Yu L., FEBS Lett. July 15, 1996; 390 (1): 63-8.

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit., Chan KW, Sui JL, Vivaudou M, Logothetis DE., Proc Natl Acad Sci U S A. November 26, 1996; 93 (24): 14193-8.

A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation., Silverman SK, Kofuji P, Dougherty DA, Davidson N, Lester HA., Proc Natl Acad Sci U S A. December 24, 1996; 93 (26): 15429-34.

Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels., Döring F, Wischmeyer E, Spauschus A, Thomzig A, Veh R, Karschin A., Mol Cell Neurosci. January 1, 1997; 9 (3): 194-206.

Specific regions of heteromeric subunits involved in enhancement of G protein-gated K+ channel activity., Chan KW, Sui JL, Vivaudou M, Logothetis DE., J Biol Chem. March 7, 1997; 272 (10): 6548-55.

Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes., Sharon D, Vorobiov D, Dascal N., J Gen Physiol. April 1, 1997; 109 (4): 477-90.        

Molecular determinants for assembly of G-protein-activated inwardly rectifying K+ channels., Woodward R, Stevens EB, Murrell-Lagnado RD., J Biol Chem. April 18, 1997; 272 (16): 10823-30.

Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons., Ehrengruber MU, Doupnik CA, Xu Y, Xu Y, Garvey J, Jasek MC, Lester HA, Davidson N., Proc Natl Acad Sci U S A. June 24, 1997; 94 (13): 7070-5.

Identification of regions that regulate the expression and activity of G protein-gated inward rectifier K+ channels in Xenopus oocytes., Stevens EB, Woodward R, Ho IH, Murrell-Lagnado R., J Physiol. September 15, 1997; 503 ( Pt 3) 547-62.

Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice., Slesinger PA, Stoffel M, Jan YN, Jan LY., Proc Natl Acad Sci U S A. October 28, 1997; 94 (22): 12210-7.

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma., Huang CL, Feng S, Hilgemann DW., Nature. February 19, 1998; 391 (6669): 803-6.

Activation of inwardly rectifying K+ channels by GABA-B receptors expressed in Xenopus oocytes., Uezono Y, Akihara M, Kaibara M, Kawano C, Shibuya I, Ueda Y, Yanagihara N, Toyohira Y, Yamashita H, Taniyama K, Izumi F., Neuroreport. March 9, 1998; 9 (4): 583-7.

Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra., Inanobe A, Yoshimoto Y, Horio Y, Morishige KI, Hibino H, Matsumoto S, Tokunaga Y, Maeda T, Hata Y, Takai Y, Kurachi Y., J Neurosci. February 1, 1999; 19 (3): 1006-17.

Molecular determinants for sodium-dependent activation of G protein-gated K+ channels., Ho IH, Murrell-Lagnado RD., J Biol Chem. March 26, 1999; 274 (13): 8639-48.

Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3., Jelacic TM, Sims SM, Clapham DE., J Membr Biol. May 15, 1999; 169 (2): 123-9.

Bombesin receptors inhibit G protein-coupled inwardly rectifying K+ channels expressed in Xenopus oocytes through a protein kinase C-dependent pathway., Stevens EB, Shah BS, Pinnock RD, Lee K., Mol Pharmacol. June 1, 1999; 55 (6): 1020-7.

The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype., Hou P, Yan S, Tang W, Nelson DJ., J Neurosci. October 1, 1999; 19 (19): 8327-36.

Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels., Ho IH, Murrell-Lagnado RD., J Physiol. November 1, 1999; 520 Pt 3 645-51.

Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis., Inanobe A, Horio Y, Fujita A, Tanemoto M, Hibino H, Inageda K, Kurachi Y., J Physiol. November 15, 1999; 521 Pt 1 19-30.

Ethanol opens G-protein-activated inwardly rectifying K+ channels., Kobayashi T, Ikeda K, Kojima H, Niki H, Yano R, Yoshioka T, Kumanishi T., Nat Neurosci. December 1, 1999; 2 (12): 1091-7.

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action., Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA, Harris RA., Nat Neurosci. December 1, 1999; 2 (12): 1084-90.

The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands., Ulens C, Daenens P, Tytgat J., Eur J Pharmacol. December 3, 1999; 385 (2-3): 239-45.

Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes., Kobayashi T, Ikeda K, Kumanishi T., Br J Pharmacol. April 1, 2000; 129 (8): 1716-22.

Impermeability of the GIRK2 weaver channel to divalent cations., Hou P, Di A, Huang P, Hansen CB, Nelson DJ., Am J Physiol Cell Physiol. May 1, 2000; 278 (5): C1038-46.

Heterologous facilitation of G protein-activated K(+) channels by beta-adrenergic stimulation via cAMP-dependent protein kinase., Müllner C, Vorobiov D, Bera AK, Uezono Y, Yakubovich D, Frohnwieser-Steinecker B, Dascal N, Schreibmayer W., J Gen Physiol. May 1, 2000; 115 (5): 547-58.              

TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel., Rogalski SL, Appleyard SM, Pattillo A, Terman GW, Chavkin C., J Biol Chem. August 18, 2000; 275 (33): 25082-8.

Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in mu-opioid receptor selectivity., Ulens C, Van Boven M, Daenens P, Tytgat J., J Pharmacol Exp Ther. September 1, 2000; 294 (3): 1024-33.

Changes in GIRK1/GIRK2 deactivation kinetics and basal activity in the presence and absence of RGS4., Ulens C, Daenens P, Tytgat J., Life Sci. September 29, 2000; 67 (19): 2305-17.

G-protein mediated gating of inward-rectifier K+ channels., Mark MD, Herlitze S., Eur J Biochem. October 1, 2000; 267 (19): 5830-6.

Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels., Slesinger PA., Biophys J. February 1, 2001; 80 (2): 707-18.

Yeast screen for constitutively active mutant G protein-activated potassium channels., Yi BA, Lin YF, Jan YN, Jan LY., Neuron. March 1, 2001; 29 (3): 657-67.

Functional properties of a truncated recombinant GIRK5 potassium channel., Salvador C, Martinez M, Mora SI, Egido W, Farias JM, Gamba G, Escobar LI., Biochim Biophys Acta. May 2, 2001; 1512 (1): 135-47.

Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels., Zhou W, Arrabit C, Choe S, Slesinger PA., Proc Natl Acad Sci U S A. May 22, 2001; 98 (11): 6482-7.

Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels., Yamakura T, Lewohl JM, Harris RA., Anesthesiology. July 1, 2001; 95 (1): 144-53.

G protein-gated inwardly rectifying potassium channels are targets for volatile anesthetics., Weigl LG, Schreibmayer W., Mol Pharmacol. August 1, 2001; 60 (2): 282-9.

The role of the hydrophilic Asn230 residue of the mu-opioid receptor in the potency of various opioid agonists., Pil J, Tytgat J., Br J Pharmacol. October 1, 2001; 134 (3): 496-506.

Does acetaldehyde mediate ethanol action in the central nervous system?, Mascia MP, Maiya R, Borghese CM, Lobo IA, Hara K, Yamakura T, Gong DH, Beckstead MJ., Alcohol Clin Exp Res. November 1, 2001; 25 (11): 1570-5.

Morphine-6beta-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies., Ulens C, Baker L, Ratka A, Waumans D, Tytgat J., Biochem Pharmacol. November 1, 2001; 62 (9): 1273-82.

A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating., Guo Y, Waldron GJ, Murrell-Lagnado R., J Biol Chem. December 13, 2002; 277 (50): 48289-94.

Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac)., Kobayashi T, Washiyama K, Ikeda K., Br J Pharmacol. March 1, 2003; 138 (6): 1119-28.

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