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Summary Expression Phenotypes Gene Literature (265) GO Terms (2) Nucleotides (54) Proteins (26) Interactants (177) Wiki
XB-GENEPAGE-962319

Papers associated with kcne1



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Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues., Bohannon BM, Jowais JJ, Nyberg L, Olivier-Meo V, Corradi V, Tieleman DP, Liin SI, Larsson HP., Elife. June 23, 2023; 12


Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1., Erlandsdotter LM, Giammarino L, Halili A, Nikesjö J, Gréen H, Odening KE, Liin SI., Sci Adv. March 17, 2023; 9 (11): eade7109.                          

Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants., Rinné S, Oertli A, Nagel C, Tomsits P, Jenewein T, Kääb S, Kauferstein S, Loewe A, Beckmann BM, Decher N., Int J Mol Sci. January 10, 2023; 24 (2):                       

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex., Kasuya G, Nakajo K., Elife. November 4, 2022; 11               

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels., Zou X, Wu X, Sampson KJ, Colecraft HM, Larsson HP, Kass RS., Front Physiol. January 1, 2022; 13 902224.                      

Virus-Host Interactions of Enteroviruses and Parvovirus B19 in Myocarditis., Ho HT, Peischard S, Strutz-Seebohm N, Seebohm G., Cell Physiol Biochem. November 18, 2021; 55 (6): 679-703.        

The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., Manville RW, Abbott GW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects., Lin Y, Grinter SZ, Lu Z, Xu X, Wang HZ, Liang H, Hou P, Gao J, Clausen C, Shi J, Zhao W, Ma Z, Liu Y, White KM, Zhao L, Kang PW, Zhang G, Cohen IS, Zou X, Cui J., Proc Natl Acad Sci U S A. May 18, 2021; 118 (20):


Compound Heterozygous KCNQ1 Mutations Causing Recessive Romano-Ward Syndrome: Functional Characterization by Mutant Co-expression., González-Garrido A, Domínguez-Pérez M, Jacobo-Albavera L, López-Ramírez O, Guevara-Chávez JG, Zepeda-García O, Iturralde P, Carnevale A, Villarreal-Molina T., Front Cardiovasc Med. February 22, 2021; 8 625449.

Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness., Oertli A, Rinné S, Moss R, Kääb S, Seemann G, Beckmann BM, Decher N., Int J Mol Sci. January 23, 2021; 22 (3):             

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics., Abbott GW, Redford KE, Yoshimura RF, Manville RW, Moreira L, Tran K, Arena G, Kookootsedes A, Lasky E, Gunnison E., Front Physiol. January 1, 2021; 12 777057.

Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo., Skarsfeldt MA, Liin SI, Larsson HP, Bentzen BH., Acta Physiol (Oxf). August 1, 2020; 229 (4): e13471.

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity., Lübke M, Schreiber JA, Le Quoc T, Körber F, Müller J, Sivanathan S, Matschke V, Schubert J, Strutz-Seebohm N, Seebohm G, Scherkenbeck J., ChemMedChem. June 17, 2020; 15 (12): 1078-1088.

4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region., Bollmann E, Schreiber JA, Ritter N, Peischard S, Ho HT, Wünsch B, Strünker T, Meuth S, Budde T, Strutz-Seebohm N, Seebohm G., Cell Physiol Biochem. April 8, 2020; 54 (2): 321-332.

Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms., Bohannon BM, de la Cruz A, Wu X, Jowais JJ, Perez ME, Dykxhoorn DM, Liin SI, Larsson HP., Elife. March 24, 2020; 9                                                               

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state., Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR., Elife. February 25, 2020; 9                                     

KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity., Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW., J Cell Physiol. August 1, 2019; 234 (8): 13361-13369.

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling., Hou P, Shi J, White KM, Gao Y, Cui J., Elife. July 22, 2019; 8                     

Probing the Dynamics and Structural Topology of the Reconstituted Human KCNQ1 Voltage Sensor Domain (Q1-VSD) in Lipid Bilayers Using Electron Paramagnetic Resonance Spectroscopy., Dixit G, Sahu ID, Reynolds WD, Wadsworth TM, Harding BD, Jaycox CK, Dabney-Smith C, Sanders CR, Lorigan GA., Biochemistry. February 19, 2019; 58 (7): 965-973.

Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation., De Silva AM, Manville RW, Abbott GW., Sci Adv. November 14, 2018; 4 (11): eaav0824.            

Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel., Drabkin M, Zilberberg N, Menahem S, Mulla W, Halperin D, Yogev Y, Wormser O, Perez Y, Kadir R, Etzion Y, Katz A, Birk OS., Circ Genom Precis Med. November 1, 2018; 11 (11): e002293.

Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results., Chua HC, Servatius H, Asatryan B, Schaller A, Rieubland C, Noti F, Seiler J, Roten L, Baldinger SH, Tanner H, Fuhrer J, Haeberlin A, Lam A, Pless SA, Medeiros-Domingo A., Clin Res Cardiol. August 1, 2018; 107 (8): 670-678.

KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site., Larsson JE, Larsson HP, Liin SI., Elife. July 17, 2018; 7           

Direct neurotransmitter activation of voltage-gated potassium channels., Manville RW, Papanikolaou M, Abbott GW., Nat Commun. May 10, 2018; 9 (1): 1847.            

Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression., Wu M, Obara Y, Ohshima S, Nagasawa Y, Ishii K., Biochem Biophys Res Commun. November 4, 2017; 493 (1): 409-415.

Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling., Lee HC, Lee HC, Rudy Y, Liang H, Chen CC, Luo CH, Sheu SH, Cui J., J Med Biol Eng. October 1, 2017; 37 (5): 780-789.          

KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions., Barro-Soria R, Ramentol R, Liin SI, Perez ME, Kass RS, Larsson HP., Proc Natl Acad Sci U S A. August 29, 2017; 114 (35): E7367-E7376.

Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium., Pedersen PJ, Thomsen KB, Flak JB, Tejada MA, Hauser F, Trachsel D, Buhl R, Kalbfleisch T, DePriest MS, MacLeod JN, Calloe K, Klaerke DA., Res Vet Sci. August 1, 2017; 113 79-86.

Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations., Peng G, Barro-Soria R, Sampson KJ, Larsson HP, Kass RS., Sci Rep. April 6, 2017; 7 45911.                

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting., Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G., Nat Commun. October 12, 2016; 7 12795.                  

The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols., Xie C, Liu HW, Pan N, Ding JP, Yao J., Acta Pharmacol Sin. January 1, 2016; 37 (1): 124-33.          

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel., Liin SI, Silverå Ejneby M, Barro-Soria R, Skarsfeldt MA, Larsson JE, Starck Härlin F, Parkkari T, Bentzen BH, Schmitt N, Larsson HP, Elinder F., Proc Natl Acad Sci U S A. May 5, 2015; 112 (18): 5714-9.          

High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB, Refaat MM, David JP, Mujezinovic A, Calloe K, Wojciak J, Nussbaum RL, Scheinman MM, Schmitt N., Sci Rep. January 12, 2015; 5 10009.              

Regulation of Voltage Gated K+ Channel KCNE1/KCNQ1 by the Janus Kinase JAK3., Warsi J, Abousaab A, Fezai M, Elvira B, Lang F., Cell Physiol Biochem. January 1, 2015; 37 (6): 2476-85.

Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites., Choi SH, Lee BH, Kim HJ, Jung SW, Kim HS, Shin HC, Lee JH, Kim HC, Rhim H, Hwang SH, Ha TS, Kim HJ, Cho H, Nah SY., Mol Cells. September 1, 2014; 37 (9): 656-63.                

Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning., Eckey K, Wrobel E, Strutz-Seebohm N, Pott L, Schmitt N, Seebohm G., J Biol Chem. August 15, 2014; 289 (33): 22749-22758.

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology., Oliveras A, Roura-Ferrer M, Solé L, de la Cruz A, Prieto A, Etxebarria A, Manils J, Morales-Cano D, Condom E, Soler C, Cogolludo A, Valenzuela C, Villarroel A, Comes N, Felipe A., Arterioscler Thromb Vasc Biol. July 1, 2014; 34 (7): 1522-30.

Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1., Wu M, Obara Y, Norota I, Nagasawa Y, Ishii K., Pflugers Arch. May 1, 2014; 466 (5): 937-46.

Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel., Zaydman MA, Kasimova MA, McFarland K, Beller Z, Hou P, Kinser HE, Liang H, Zhang G, Shi J, Tarek M, Cui J., Elife. March 12, 2014; 3 e03606.                        

Upregulation of KCNQ1/KCNE1 K+ channels by Klotho., Almilaji A, Pakladok T, Muñoz C, Elvira B, Sopjani M, Lang F., Channels (Austin). January 1, 2014; 8 (3): 222-9.

Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks)., Li Y, Gao J, Lu Z, McFarland K, Shi J, Bock K, Cohen IS, Cui J., Proc Natl Acad Sci U S A. November 19, 2013; 110 (47): 18922-7.

Inhibition of ROMK channels by low extracellular K+ and oxidative stress., Frindt G, Li H, Sackin H, Palmer LG., Am J Physiol Renal Physiol. July 15, 2013; 305 (2): F208-15.

Differential effects of ginsenoside metabolites on slowly activating delayed rectifier K(+) and KCNQ1 K(+) channel currents., Choi SH, Lee BH, Kim HJ, Jung SW, Hwang SH, Nah SY., J Ginseng Res. July 1, 2013; 37 (3): 324-31.          

Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling., Park DS, Seo JH, Hong M, Choi SC., Biochem Biophys Res Commun. June 28, 2013; 436 (2): 338-43.        

Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome., Hoosien M, Ahearn ME, Myerburg RJ, Pham TV, Miller TE, Smets MJ, Baumbach-Reardon L, Young ML, Farooq A, Bishopric NH., Heart Rhythm. May 1, 2013; 10 (5): 728-37.

Purinergic signalling - a possible mechanism for KCNQ1 channel response to cell volume challenges., Hammami S, Willumsen NJ, Meinild AK, Klaerke DA, Novak I., Acta Physiol (Oxf). March 1, 2013; 207 (3): 503-15.

Chemical derivatization and purification of peptide-toxins for probing ion channel complexes., Hua Z, Kobertz WR., Methods Mol Biol. January 1, 2013; 995 19-30.

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation., Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Rüttiger L, Knipper M, Lang F., FASEB J. October 1, 2012; 26 (10): 4243-53.

Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A., Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.

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