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Summary Expression Phenotypes Gene Literature (24) GO Terms (0) Nucleotides (48) Proteins (25) Interactants (38) Wiki

Papers associated with kcnq5

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Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity., Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K., J Biol Chem. July 21, 2000; 275 (29): 22395-400.

Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells., Wickenden AD, Zou A, Wagoner PK, Jegla T., Br J Pharmacol. January 1, 2001; 132 (2): 381-4.

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly., Schwake M, Jentsch TJ, Friedrich T., EMBO Rep. January 1, 2003; 4 (1): 76-81.

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine., Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M., J Neurosci. May 18, 2005; 25 (20): 5051-60.

The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes., Jensen HS, Callø K, Jespersen T, Jensen BS, Olesen SP., Brain Res Mol Brain Res. September 13, 2005; 139 (1): 52-62.

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly., Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P, Friedrich T., J Neurosci. April 5, 2006; 26 (14): 3757-66.

Inactivation as a new regulatory mechanism for neuronal Kv7 channels., Jensen HS, Grunnet M, Olesen SP., Biophys J. April 15, 2007; 92 (8): 2747-56.

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2., Ekberg J, Schuetz F, Boase NA, Conroy SJ, Manning J, Kumar S, Poronnik P, Adams DJ., J Biol Chem. April 20, 2007; 282 (16): 12135-42.

A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels., Fedorenko O, Strutz-Seebohm N, Henrion U, Ureche ON, Lang F, Seebohm G, Lang UE., Psychopharmacology (Berl). July 1, 2008; 199 (1): 47-54.

Expression profile and characterisation of a truncated KCNQ5 splice variant., Yeung SY, Lange W, Schwake M, Greenwood IA., Biochem Biophys Res Commun. July 11, 2008; 371 (4): 741-6.

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents., Yeung S, Schwake M, Pucovský V, Greenwood Ia., Br J Pharmacol. September 1, 2008; 155 (1): 62-72.

Functional implications of KCNE subunit expression for the Kv7.5 (KCNQ5) channel., Roura-Ferrer M, Etxebarria A, Solé L, Oliveras A, Comes N, Villarroel A, Felipe A., Cell Physiol Biochem. January 1, 2009; 24 (5-6): 325-34.

The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes., Blom SM, Schmitt N, Jensen HS., PLoS One. December 11, 2009; 4 (12): e8251.                  

The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus., Tzingounis AV, Heidenreich M, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll RA, Jentsch TJ., Proc Natl Acad Sci U S A. June 1, 2010; 107 (22): 10232-7.

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders., Gilling M, Rasmussen HB, Calloe K, Sequeira AF, Baretto M, Oliveira G, Almeida J, Lauritsen MB, Ullmann R, Boonen SE, Brondum-Nielsen K, Kalscheuer VM, Tümer Z, Vicente AM, Schmitt N, Tommerup N., Front Genet. April 16, 2013; 4 54.                  

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology., Oliveras A, Roura-Ferrer M, Solé L, de la Cruz A, Prieto A, Etxebarria A, Manils J, Morales-Cano D, Condom E, Soler C, Cogolludo A, Valenzuela C, Villarroel A, Comes N, Felipe A., Arterioscler Thromb Vasc Biol. July 1, 2014; 34 (7): 1522-30.

4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries., Khammy MM, Kim S, Bentzen BH, Lee S, Choi I, Aalkjaer C, Jepps TA., Br J Pharmacol. February 1, 2018; 175 (3): 501-516.

Direct neurotransmitter activation of voltage-gated potassium channels., Manville RW, Papanikolaou M, Abbott GW., Nat Commun. May 10, 2018; 9 (1): 1847.            

Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels., Manville RW, Abbott GW., Mol Pharmacol. October 1, 2018; 94 (4): 1155-1163.

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner., Manville RW, Abbott GW., Commun Biol. February 22, 2019; 2 401.                    

The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator., Redford KE, Abbott GW., Commun Biol. July 8, 2020; 3 (1): 356.

The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., Manville RW, Abbott GW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.

KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine., Manville RW, Redford KE, van der Horst J, Hogenkamp DJ, Jepps TA, Abbott GW., FASEB J. September 1, 2022; 36 (9): e22457.

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