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Summary Expression Phenotypes Gene Literature (51) GO Terms (10) Nucleotides (108) Proteins (45) Interactants (445) Wiki

Papers associated with lrp5

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6 paper(s) referencing morpholinos

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A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals., Hong JY, Zapata J, Blackburn A, Baumert R, Bae SM, Ji H, Nam HJ, Miller RK, McCrea PD., Biochem Biophys Res Commun. July 23, 2021; 563 31-39.        

Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevis., Carr BJ, Stanar P, Moritz OL., J Cell Sci. January 11, 2021; 134 (1):                           

Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner., Devotta A, Hong CS, Saint-Jeannet JP., Elife. July 23, 2018; 7                             

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover., Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C., Dev Cell. October 9, 2017; 43 (1): 71-82.e6.                                

Genome evolution in the allotetraploid frog Xenopus laevis., Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS., Nature. October 20, 2016; 538 (7625): 336-343.                              

Aberrant regulation of Wnt signaling in hepatocellular carcinoma., Liu LJ, Xie SX, Chen YT, Xue JL, Zhang CJ, Zhu F., World J Gastroenterol. September 7, 2016; 22 (33): 7486-99.      

Affinity of the heparin binding motif of Noggin1 to heparan sulfate and its visualization in the embryonic tissues., Nesterenko AM, Orlov EE, Ermakova GV, Ivanov IA, Semenyuk PI, Orlov VN, Martynova NY, Zaraisky AG., Biochem Biophys Res Commun. December 4, 2015; 468 (1-2): 331-6.        

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan., Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY., Elife. July 9, 2015; 4                               

Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development., Sokol SY., Semin Cell Dev Biol. June 1, 2015; 42 78-85.      

Early development of the neural plate: new roles for apoptosis and for one of its main effectors caspase-3., Juraver-Geslin HA, Durand BC., Genesis. February 1, 2015; 53 (2): 203-24.          

A Molecular atlas of Xenopus respiratory system development., Rankin SA, Rankin SA, Thi Tran H, Wlizla M, Mancini P, Shifley ET, Bloor SD, Han L, Vleminckx K, Vleminckx K, Wert SE, Zorn AM., Dev Dyn. January 1, 2015; 244 (1): 69-85.                    

Organophosphate pesticides induce morphological abnormalities and decrease locomotor activity and heart rate in Danio rerio and Xenopus laevis., Watson FL, Schmidt H, Turman ZK, Hole N, Garcia H, Gregg J, Tilghman J, Fradinger EA., Environ Toxicol Chem. June 1, 2014; 33 (6): 1337-45.

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength., de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.          

[New Development in Osteoporosis Treatment. Anti-Dickkopf1 (Dkk1) antibody as a bone anabolic agent for the treatment of osteoporosis]., Tai N, Inoue D., Clin Calcium. January 1, 2014; 24 (1): 75-83.

RAB8B is required for activity and caveolar endocytosis of LRP6., Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C, Boutros M., Cell Rep. September 26, 2013; 4 (6): 1224-34.                    

Crystal structures of Lgr4 and its complex with R-spondin1., Xu K, Xu Y, Xu Y, Rajashankar KR, Robev D, Nikolov DB., Structure. September 3, 2013; 21 (9): 1683-9.

structural Studies of Wnts and identification of an LRP6 binding site., Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI., Structure. July 2, 2013; 21 (7): 1235-42.

β-Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements., Kim GH, Park EC, Lee H, Lee H, Na HJ, Choi SC, Han JK., Biochem Biophys Res Commun. May 31, 2013; 435 (2): 182-7.                  

Maternal xNorrin, a canonical Wnt signaling agonist and TGF-β antagonist, controls early neuroectoderm specification in Xenopus., Xu S, Cheng F, Liang J, Wu W, Zhang J., PLoS Biol. January 1, 2012; 10 (3): e1001286.                                    

Engineering of an artificial light-modulated potassium channel., Caro LN, Moreau CJ, Estrada-Mondragón A, Ernst OP, Vivaudou M., PLoS One. January 1, 2012; 7 (8): e43766.          

Effects of natural compounds on Xenopus embryogenesis: a potential read out for functional drug discovery targeting Wnt/β-catenin signaling., Amado NG, Fonseca BF, Cerqueira DM, Reis AH, Simas AB, Kuster RM, Mendes FA, Abreu JG., Curr Top Med Chem. January 1, 2012; 12 (19): 2103-13.

Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation., Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W., Mol Cell Biol. July 1, 2011; 31 (13): 2577-90.

INOH: ontology-based highly structured database of signal transduction pathways., Yamamoto S, Sakai N, Nakamura H, Fukagawa H, Fukuda K, Takagi T., Database (Oxford). May 17, 2011; 2011 bar052.                

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members., Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD., J Cell Sci. December 15, 2010; 123 (Pt 24): 4351-65.

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex., Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Brivanlou AH, Barres BA, Christiano AM., Nature. April 15, 2010; 464 (7291): 1043-7.      

Macrophage Wnt7b is critical for kidney repair and regeneration., Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS., Proc Natl Acad Sci U S A. March 2, 2010; 107 (9): 4194-9.      

Cell cycle control of wnt receptor activation., Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C., Dev Cell. December 1, 2009; 17 (6): 788-99.    

Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling., Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W., PLoS One. November 24, 2009; 4 (11): e7982.            

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo., Bryja V, Andersson ER, Schambony A, Esner M, Bryjová L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E., Mol Biol Cell. February 1, 2009; 20 (3): 924-36.        

Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6., Wu G, Huang H, Garcia Abreu J, He X., PLoS One. January 1, 2009; 4 (3): e4926.              

A novel activity of the Dickkopf-1 amino terminal domain promotes axial and heart development independently of canonical Wnt inhibition., Korol O, Gupta RW, Mercola M., Dev Biol. December 1, 2008; 324 (1): 131-8.

Parathyroid hormone signaling through low-density lipoprotein-related protein 6., Wan M, Yang C, Li J, Wu X, Yuan H, Ma H, He X, Nie S, Chang C, Cao X., Genes Dev. November 1, 2008; 22 (21): 2968-79.  

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3''s phosphorylation of beta-catenin., Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E, Lee E., Proc Natl Acad Sci U S A. June 10, 2008; 105 (23): 8032-7.        

Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6., MacDonald BT, Yokota C, Tamai K, Zeng X, He X., J Biol Chem. June 6, 2008; 283 (23): 16115-23.

The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology., Nakamura T, Nakamura T, Matsumoto K., J Cell Mol Med. April 1, 2008; 12 (2): 391-408.          

Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen., Cselenyi CS, Lee E, Lee E., Sci Signal. February 26, 2008; 1 (8): pe10.

Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling., Hassler C, Cruciat CM, Huang YL, Kuriyama S, Mayor R, Niehrs C., Development. December 1, 2007; 134 (23): 4255-63.      

Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek., Caneparo L, Huang YL, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C, Houart C., Genes Dev. February 15, 2007; 21 (4): 465-80.

Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin., Kofron M, Birsoy B, Houston D, Tao Q, Tao Q, Wylie C, Heasman J., Development. February 1, 2007; 134 (3): 503-13.      

Function and biological roles of the Dickkopf family of Wnt modulators., Niehrs C., Oncogene. December 4, 2006; 25 (57): 7469-81.

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity., Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R., J Bone Miner Res. November 1, 2006; 21 (11): 1738-49.              

beta-Catenin controls cell sorting at the notochord-somite boundary independently of cadherin-mediated adhesion., Reintsch WE, Habring-Mueller A, Wang RW, Schohl A, Fagotto F., J Cell Biol. August 15, 2005; 170 (4): 675-86.              

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor., Semënov M, Tamai K, He X., J Biol Chem. July 22, 2005; 280 (29): 26770-5.

Comparative genomics on Dkk1 orthologs., Katoh Y, Katoh M., Int J Oncol. July 1, 2005; 27 (1): 275-9.

Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development., Bonfanti P, Colombo A, Orsi F, Nizzetto I, Andrioletti M, Bacchetta R, Mantecca P, Fascio U, Vailati G, Vismara C., Aquat Toxicol. December 10, 2004; 70 (3): 189-200.

Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticides., Smulders CJ, Bueters TJ, Vailati S, van Kleef RG, Vijverberg HP., Toxicol Sci. December 1, 2004; 82 (2): 545-54.

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling., Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO., J Biol Chem. September 20, 2002; 277 (38): 34727-35.                

Cloning and expression of Xenopus Lrp5 and Lrp6 genes., Houston DW, Wylie C., Mech Dev. September 1, 2002; 117 (1-2): 337-42.      

Multiple stage-dependent roles for histone deacetylases during amphibian embryogenesis: implications for the involvement of extracellular matrix remodeling., Damjanovski S, Sachs LM, Shi YB, Shi YB., Int J Dev Biol. October 1, 2000; 44 (7): 769-76.                    

LDL-receptor-related proteins in Wnt signal transduction., Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X., Nature. September 28, 2000; 407 (6803): 530-5.

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