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Summary Expression Phenotypes Gene Literature (609) GO Terms (2) Nucleotides (339) Proteins (9) Interactants (685) Wiki
XB--6457939

Papers associated with gabarap



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Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1., Ramesh SA, Long Y, Dashtbani-Roozbehani A, Gilliham M, Brown MH, Tyerman SD., Biology (Basel). August 2, 2022; 11 (8):


Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABAA receptors by two distinct mechanisms., Bampali K, Koniuszewski F, Silva LL, Rehman S, Vogel FD, Seidel T, Scholze P, Zirpel F, Garon A, Langer T, Willeit M, Ernst M., Br J Pharmacol. July 1, 2022; 179 (14): 3675-3692.


Unexpected Effect of IL-1β on the Function of GABAA Receptors in Pediatric Focal Cortical Dysplasia., Alfano V, Romagnolo A, Mills JD, Cifelli P, Gaeta A, Morano A, Mühlebner A, Aronica E, Palma E, Ruffolo G., Brain Sci. June 19, 2022; 12 (6):


Clerodane Diterpenes from Casearia corymbosa as Allosteric GABAA Receptor Modulators., Syafni N, Faleschini MT, Garifulina A, Danton O, Gupta MP, Hering S, Hamburger M., J Nat Prod. May 27, 2022; 85 (5): 1201-1210.


The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State., Pierce SR, Germann AL, Steinbach JH, Akk G., Mol Pharmacol. February 1, 2022; 101 (2): 68-77.


Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate., Brosnan RJ, Ramos K, Aguiar AJA, Cenani A, Knych HK., Pharmacology. January 1, 2022; 107 (3-4): 167-178.


High-Dose Benzodiazepines Positively Modulate GABAA Receptors via a Flumazenil-Insensitive Mechanism., Wang N, Lian J, Cao Y, Muheyati A, Yuan S, Ma Y, Zhang S, Yu G, Su R., Int J Mol Sci. December 21, 2021; 23 (1):


GABAA Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil., Soualah Z, Taly A, Crespin L, Saulais O, Henrion D, Legendre C, Tricoire-Leignel H, Legros C, Mattei C., Front Neurosci. November 29, 2021; 15 768466.


Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)., Madjroh N, Mellou E, Davies PA, Söderhielm PC, Jensen AA., Biochem Pharmacol. November 1, 2021; 193 114782.


Stigmasterol can be new steroidal drug for neurological disorders: Evidence of the GABAergic mechanism via receptor modulation., Karim N, Khan I, Abdelhalim A, Halim SA, Khan A, Al-Harrasi A., Phytomedicine. September 1, 2021; 90 153646.


Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site., Sridhar A, Lummis SCR, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ, Ulens C., J Biol Chem. August 1, 2021; 297 (2): 100899.  


Substituted Cysteine Modification and Protection with n-Alkyl- Methanethiosulfonate Reagents Yields a Precise Estimate of the Distance between Etomidate and a Residue in Activated GABA Type A Receptors., Fantasia RJ, Nourmahnad A, Halpin E, Forman SA., Mol Pharmacol. June 1, 2021; 99 (6): 426-434.


Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man., Hipp JF, Knoflach F, Comley R, Ballard TM, Honer M, Trube G, Gasser R, Prinssen E, Wallace TL, Rothfuss A, Knust H, Lennon-Chrimes S, Derks M, Bentley D, Squassante L, Nave S, Nöldeke J, Wandel C, Thomas AW, Hernandez MC., Sci Rep. April 8, 2021; 11 (1): 7700.


Efficient expression of concatenated α1β2δ and α1β3δ GABAA receptors, their pharmacology and stoichiometry., Liao VWY, Chebib M, Ahring PK., Br J Pharmacol. April 1, 2021; 178 (7): 1556-1573.


Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy., Cifelli P, Di Angelantonio S, Alfano V, Morano A, De Felice E, Aronica E, Ruffolo G, Palma E., Brain Sci. March 30, 2021; 11 (4):                 


Targeting GABAC Receptors Improves Post-Stroke Motor Recovery., van Nieuwenhuijzen PS, Parker K, Liao V, Houlton J, Kim HL, Johnston GAR, Hanrahan JR, Chebib M, Clarkson AN., Brain Sci. March 2, 2021; 11 (3):                 


Characterization of the GABRB2-Associated Neurodevelopmental Disorders., El Achkar CM, Harrer M, Smith L, Kelly M, Iqbal S, Maljevic S, Niturad CE, Vissers LELM, Poduri A, Yang E, Lal D, Lerche H, Møller RS, Olson HE, null null., Ann Neurol. March 1, 2021; 89 (3): 573-586.      


Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix., Borghese CM, Wang HL, McHardy SF, Messing RO, Trudell JR, Harris RA, Bertaccini EJ., Proc Natl Acad Sci U S A. February 23, 2021; 118 (8):           


Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABAA and Nicotinic Acetylcholine Receptors., Son L, Kryukova E, Ziganshin R, Andreeva T, Kudryavtsev D, Kasheverov I, Tsetlin V, Utkin Y., Toxins (Basel). February 20, 2021; 13 (2):


A critical residue in the α1M2-M3 linker regulating mammalian GABAA receptor pore gating by diazepam., Nors JW, Gupta S, Goldschen-Ohm MP., Elife. February 16, 2021; 10                       


''Proximity frequencies'' a new parameter to evaluate the profile of GABAAR modulators., Crocetti L, Guerrini G, Cantini N, Vergelli C, Melani F, Mascia MP, Giovannoni MP., Bioorg Med Chem Lett. February 15, 2021; 34 127755.


GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties., Ordaz RP, Garay E, Limon A, Pérez-Samartín A, Sánchez-Gómez MV, Robles-Martínez L, Cisneros-Mejorado A, Matute C, Arellano RO., Mol Pharmacol. February 1, 2021; 99 (2): 133-146.


The anticonvulsant zonisamide positively modulates recombinant and native glycine receptors at clinically relevant concentrations., Devenish SO, Winters BL, Anderson LL, Arnold JC, McGregor IS, Vaughan CW, Chebib M, Absalom NL., Neuropharmacology. January 1, 2021; 182 108371.


A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C., Simeone X, Koniuszewski F, Müllegger M, Smetka A, Steudle F, Puthenkalam R, Ernst M, Scholze P., Mol Pharmacol. January 1, 2021; 99 (1): 39-48.            


Reduced Activation of the Synaptic-Type GABAA Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization., Pierce SR, Germann AL, Evers AS, Steinbach JH, Akk G., Mol Pharmacol. December 1, 2020; 98 (6): 762-769.


In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders., Grupe M, Bentzen BH, Benned-Jensen T, Nielsen V, Frederiksen K, Jensen HS, Jacobsen AM, Skibsbye L, Sams AG, Grunnet M, Rottländer M, Bastlund JF., Eur J Pharmacol. November 15, 2020; 887 173440.


PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea stagnalis., Vulfius CA, Lebedev DS, Kryukova EV, Kudryavtsev DS, Kolbaev SN, Utkin YN, Tsetlin VI., J Neurochem. November 1, 2020; 155 (3): 274-284.


Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling., Blednov YA, Borghese CM, Dugan MP, Pradhan S, Thodati TM, Kichili NR, Harris RA, Messing RO., Neuropharmacology. November 1, 2020; 178 108220.


The desensitization pathway of GABAA receptors, one subunit at a time., Gielen M, Barilone N, Corringer PJ., Nat Commun. October 23, 2020; 11 (1): 5369.                


Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites., Germann AL, Reichert DE, Burbridge AB, Pierce SR, Evers AS, Steinbach JH, Akk G., Mol Pharmacol. October 1, 2020; 98 (4): 280-291.


Site-specific effects of neurosteroids on GABAA receptor activation and desensitization., Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS., Elife. September 21, 2020; 9   


Erythropoietin Increases GABAA Currents in Human Cortex from TLE Patients., Roseti C, Cifelli P, Ruffolo G, Barbieri E, Guescini M, Esposito V, Di Gennaro G, Limatola C, Giovannelli A, Aronica E, Palma E., Neuroscience. July 15, 2020; 439 153-162.


Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome., Ruffolo G, Cifelli P, Miranda-Lourenço C, De Felice E, Limatola C, Sebastião AM, Diógenes MJ, Aronica E, Palma E., Neuroscience. July 15, 2020; 439 146-152.


Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy., Hannan S, Affandi AHB, Minere M, Jones C, Goh P, Warnes G, Popp B, Trollmann R, Nizetic D, Smart TG., J Neurosci. July 15, 2020; 40 (29): 5518-5530.


Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions., Ihara M, Furutani S, Shigetou S, Shimada S, Niki K, Komori Y, Kamiya M, Koizumi W, Magara L, Hikida M, Noguchi A, Okuhara D, Yoshinari Y, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K., Proc Natl Acad Sci U S A. July 14, 2020; 117 (28): 16283-16291.        


A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors., Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW., Eur J Med Chem. May 15, 2020; 194 112261.


Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors., Niespodziany I, Ghisdal P, Mullier B, Wood M, Provins L, Kaminski RM, Wolff C., Epilepsia. May 1, 2020; 61 (5): 914-923.                


Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons., Joshi S, Roden WH, Kapur J, Jansen LA., Ann Clin Transl Neurol. April 1, 2020; 7 (4): 527-542.            


Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro., Tukker AM, Bouwman LMS, van Kleef RGDM, Hendriks HS, Legler J, Westerink RHS., Sci Rep. March 24, 2020; 10 (1): 5311.


Cloning and Expression of Cockroach α7 Nicotinic Acetylcholine Receptor Subunit., Cartereau A, Taillebois E, Selvam B, Martin C, Graton J, Le Questel JY, Thany SH., Front Physiol. February 18, 2020; 11 418.            


The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents., McGrath M, Tolia M, Raines DE., Pharmacol Rep. February 1, 2020; 72 (1): 260-266.


Competitive Antagonism of Etomidate Action by Diazepam., McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE., Anesthesiology. January 1, 2020; 133 (3): 583-594.


Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits., Yang X, Jounaidi Y, Mukherjee K, Fantasia RJ, Liao EC, Yu B, Forman SA., Anesthesiology. December 1, 2019; 131 (6): 1276-1291.


Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo., Kent DE, Savechenkov PY, Bruzik KS, Miller KW., Br J Pharmacol. December 1, 2019; 176 (24): 4760-4772.


Steady-state activation of the high-affinity isoform of the α4β2δ GABAA receptor., Pierce SR, Senneff TC, Germann AL, Akk G., Sci Rep. November 5, 2019; 9 (1): 15997.


Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions., Anderson LL, Absalom NL, Abelev SV, Low IK, Doohan PT, Martin LJ, Chebib M, McGregor IS, Arnold JC., Epilepsia. November 1, 2019; 60 (11): 2224-2234.                    


Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents., Bian X, Zhang Y, Huang B, Wang X, Wang G, Zhu Y, Liu Y, Liang J, Jia Y, Wang K., Eur J Pharmacol. September 5, 2019; 858 172496.


Steady-State Activation and Modulation of the Concatemeric α1β2γ2L GABAA Receptor., Germann AL, Pierce SR, Burbridge AB, Steinbach JH, Akk G., Mol Pharmacol. September 1, 2019; 96 (3): 320-329.


Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands., Germann AL, Pierce SR, Senneff TC, Burbridge AB, Steinbach JH, Akk G., Physiol Rep. September 1, 2019; 7 (18): e14230.              


A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin., Faleschini MT, Maier A, Fankhauser S, Thasis K, Hebeisen S, Hamburger M, Butterweck V., Planta Med. August 1, 2019; 85 (11-12): 925-933.

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