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Summary Expression Phenotypes Gene Literature (28) GO Terms (9) Nucleotides (364) Proteins (38) Interactants (241) Wiki

Papers associated with top2a

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Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms., Van Ravenstein SX, Mehta KP, Kavlashvili T, Byl JAW, Zhao R, Osheroff N, Cortez D, Dewar JM., EMBO J. January 1, 2022; 41 (12): e110632.

Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization., Choppakatla P, Dekker B, Cutts EE, Vannini A, Dekker J, Funabiki H., Elife. August 18, 2021; 10                           

Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly., Shintomi K, Hirano T., Nat Commun. May 18, 2021; 12 (1): 2917.            

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination., Heintzman DR, Campos LV, Byl JAW, Osheroff N, Dewar JM., Cell Rep. October 8, 2019; 29 (2): 422-436.e5.                

Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells., Zhang Z, Lei A, Xu L, Chen L, Chen Y, Chen Y, Zhang X, Gao Y, Yang X, Zhang M, Cao Y, Cao Y., J Biol Chem. August 4, 2017; 292 (31): 12842-12859.        

SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis., Yoshida MM, Ting L, Gygi SP, Azuma Y., J Cell Biol. June 20, 2016; 213 (6): 665-78.                

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts., Aparicio T, Baer R, Gottesman M, Gautier J., J Cell Biol. February 15, 2016; 212 (4): 399-408.            

DNA double-strand breaks with 5'' adducts are efficiently channeled to the DNA2-mediated resection pathway., Tammaro M, Liao S, Beeharry N, Yan H., Nucleic Acids Res. January 8, 2016; 44 (1): 221-31.                

The mechanism of DNA replication termination in vertebrates., Dewar JM, Budzowska M, Walter JC., Nature. September 17, 2015; 525 (7569): 345-50.                            

Reconstitution of mitotic chromatids with a minimum set of purified factors., Shintomi K, Takahashi TS, Hirano T., Nat Cell Biol. August 1, 2015; 17 (8): 1014-23.

Termination of DNA replication forks: "Breaking up is hard to do"., Bailey R, Priego Moreno S, Gambus A., Nucleus. January 1, 2015; 6 (3): 187-96.      

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1., Poh WT, Chadha GS, Gillespie PJ, Kaldis P, Blow JJ., Open Biol. January 8, 2014; 4 130138.                

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts., Gaggioli V, Le Viet B, Germe T, Hyrien O., Nucleic Acids Res. August 1, 2013; 41 (15): 7313-31.                

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants., Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN., BMC Dev Biol. November 23, 2011; 11 71.                  

The relative ratio of condensin I to II determines chromosome shapes., Shintomi K, Hirano T., Genes Dev. July 15, 2011; 25 (14): 1464-9.        

A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition., Cuvier O, Stanojcic S, Lemaitre JM, Mechali M., Genes Dev. April 1, 2008; 22 (7): 860-5.

Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer., Woenckhaus M, Merk J, Stoehr R, Schaeper F, Gaumann A, Wiebe K, Hartmann A, Hofstaedter F, Dietmaier W., Hum Pathol. January 1, 2008; 39 (1): 126-36.

Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure., Germe T, Hyrien O., EMBO Rep. August 1, 2005; 6 (8): 729-35.

A role of topoisomerase II in linking DNA replication to chromosome condensation., Cuvier O, Hirano T., J Cell Biol. March 3, 2003; 160 (5): 645-55.              

Topoisomerase II can unlink replicating DNA by precatenane removal., Lucas I, Germe T, Chevrier-Miller M, Hyrien O., EMBO J. November 15, 2001; 20 (22): 6509-19.

Characterization of vertebrate cohesin complexes and their regulation in prophase., Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM., J Cell Biol. November 13, 2000; 151 (4): 749-62.                    

A monoclonal antibody against DNA topoisomerase II labels the axial granules of Pleurodeles lampbrush chromosomes., Hock R, Carl M, Lieb B, Gebauer D, Scheer U., Chromosoma. January 1, 1996; 104 (5): 358-66.

Topoisomerase II expression and VM-26 induction of DNA breaks during spermatogenesis in Xenopus laevis., Morse-Gaudio M, Risley MS., J Cell Sci. October 1, 1994; 107 ( Pt 10) 2887-98.

An RNase-sensitive particle containing Drosophila melanogaster DNA topoisomerase II., Meller VH, McConnell M, Fisher PA., J Cell Biol. September 1, 1994; 126 (6): 1331-40.

DNA topoisomerase II is not detectable on lampbrush chromosomes but enriched in the amplified nucleoli of Xenopus oocytes., Fischer D, Hock R, Scheer U., Exp Cell Res. December 1, 1993; 209 (2): 255-60.

Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts., Hirano T, Mitchison TJ., J Cell Biol. February 1, 1993; 120 (3): 601-12.

Cell cycle control of higher-order chromatin assembly around naked DNA in vitro., Hirano T, Mitchison TJ., J Cell Biol. December 1, 1991; 115 (6): 1479-89.

Chromosome assembly in vitro: topoisomerase II is required for condensation., Adachi Y, Luke M, Laemmli UK., Cell. January 11, 1991; 64 (1): 137-48.

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