| Monarch Ortholog Phenotypes
|
Human (24 sources):
Ankle clonus,
Ataxia,
Babinski sign,
Cerebellar atrophy,
Cerebral atrophy,
Dysmetria,
Fasciculations,
Flexion contracture,
Head titubation,
Hyperreflexia,
Intention tremor,
Myokymia,
Myopia,
Myotonia,
Neurodegeneration,
Nystagmus,
Optic atrophy,
Pes cavus,
Pes planus,
Progressive visual loss,
Sensorimotor neuropathy,
Spastic paraplegia,
Tetraparesis,
Visual loss
[+]
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Mouse (33 sources):
abnormal circulating alkaline phosphatase level,
abnormal dorsal root ganglion morphology,
abnormal endplate potential,
abnormal hindlimb morphology,
abnormal large unstained cell number,
abnormal locomotor coordination,
abnormal medulla oblongata morphology,
abnormal miniature endplate potential,
abnormal neuromuscular synapse morphology,
abnormal prepulse inhibition,
abnormal spinal cord dorsal column morphology,
abnormal spine curvature,
abnormal synaptic plasticity,
axonal dystrophy,
cardiovascular system phenotype,
decreased grip strength,
decreased neurotransmitter release,
decreased paired-pulse facilitation,
digestive/alimentary phenotype,
forelimb paralysis,
hematopoietic system phenotype,
hindlimb paralysis,
increased circulating alkaline phosphatase level,
increased coping response,
increased large unstained cell number,
increased prepulse inhibition,
increased synaptic depression,
increased thermal nociceptive threshold,
limb grasping,
liver/biliary system phenotype,
premature death,
renal/urinary system phenotype,
respiratory system phenotype
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.