map3k14 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-1003187

Gene Symbol: map3k14 Gene Name: mitogen-activated protein kinase kinase kinase 14

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: map3k14 assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (63 sources): abnormal B cell activation, abnormal NK T cell morphology, abnormal Peyer's patch morphology, abnormal T cell activation, abnormal bile duct morphology, abnormal class switch recombination, abnormal dendritic cell antigen presentation, abnormal dendritic cell physiology, abnormal hepatobiliary system morphology, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal lymphopoiesis, abnormal mammary fat pad morphology, abnormal mammary gland development, abnormal spleen B cell follicle morphology, abnormal spleen marginal zone morphology, abnormal spleen primary B follicle morphology, abnormal thymus cell ratio, abnormal thymus corticomedullary boundary morphology, abnormal thymus medulla morphology, abnormal thymus morphology, absent Peyer's patches, absent axillary lymph nodes, absent cervical lymph nodes, absent follicular dendritic cells, absent inguinal lymph nodes, absent lymph nodes, absent mesenteric lymph nodes, absent popliteal lymph nodes, absent spleen marginal zone, absent thymus corticomedullary boundary, arrested B cell differentiation, decreased B cell proliferation, decreased B-1 B cell number, decreased B-2 B cell number, decreased IgG1 level, decreased IgG2b level, decreased NK T cell number, decreased Peyer's patch number, decreased circulating interferon-gamma level, decreased circulating interleukin-4 level, decreased dendritic cell number, decreased follicular B cell number, decreased germinal center B cell number, decreased mammary fat pad weight, decreased marginal zone B cell number, decreased mast cell number, decreased regulatory T cell number, decreased transitional stage T1 B cell number, decreased transitional stage T2 B cell number, dilated bile duct, enlarged lymph nodes, immune system phenotype, increased length of allograft survival, increased marginal zone B cell number, increased mature B cell number, increased susceptibility to parasitic infection, lacrimal gland inflammation, premature death, small axillary lymph nodes, small brachial lymph nodes, small thymus, thymus cyst [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (63 sources): abnormal B cell activation, abnormal NK T cell morphology, abnormal Peyer's patch morphology, abnormal T cell activation, abnormal bile duct morphology, abnormal class switch recombination, abnormal dendritic cell antigen presentation, abnormal dendritic cell physiology, abnormal hepatobiliary system morphology, abnormal intestinal epithelium morphology, [+]