| Monarch Ortholog Phenotypes
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Human (20 sources):
Abnormal pinna morphology,
Absent speech,
Agenesis of corpus callosum,
Depressed nasal bridge,
Epicanthus,
Generalized hypotonia,
Global developmental delay,
Growth delay,
Hypertelorism,
Hypotonia,
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Mouse (26 sources):
abnormal axon extension,
abnormal axon morphology,
abnormal cerebellar cortex morphology,
abnormal cerebellar foliation,
abnormal cerebral cortex morphology,
abnormal cortical ventricular zone morphology,
abnormal hippocampus granule cell layer,
abnormal hippocampus pyramidal cell layer,
abnormal neocortex morphology,
abnormal nervous system development,
abnormal neuronal precursor proliferation,
abnormal neuron differentiation,
abnormal neuron physiology,
abnormal postnatal subventricular zone morphology,
abnormal radial glial cell morphology,
abnormal stratification in cerebral cortex,
abnormal subplate morphology,
decreased body size,
decreased brain size,
decreased neuron number,
increased neuronal precursor cell number,
increased neuron apoptosis,
neonatal lethality, complete penetrance,
postnatal lethality,
small hippocampus,
thin cerebral cortex
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.