vrk1 Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (322)

Interactants (83)

XB-GENEPAGE-1003795

Gene Symbol: vrk1 Gene Name: VRK serine/threonine kinase 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: vrk1 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (21 sources): Abnormal foot morphology, Ataxia, Basal ganglia gliosis, Cerebellar hypoplasia, Congenital contracture, Degeneration of anterior horn cells, EMG: neuropathic changes, Fasciculations, Feeding difficulties in infancy, Generalized hypotonia, Global developmental delay, Hyperreflexia, Hypoplasia of the pons, Hypoplasia of the ventral pons, Hypotonia, Intellectual disability, Muscle weakness, Neuronal loss in basal ganglia, Psychomotor retardation, Respiratory insufficiency, Spinal muscular atrophy [+]
Mouse (16 sources): abnormal QRS complex, abnormal epididymis morphology, abnormal seminiferous tubule morphology, abnormal spermatid morphology, abnormal spermatogonia proliferation, arrest of male meiosis, decreased male germ cell number, decreased red blood cell distribution width, decreased respiratory quotient, improved glucose tolerance, increased circulating creatinine level, increased circulating fructosamine level, no abnormal phenotype detected, preweaning lethality, complete penetrance, prolonged QRS complex duration, seminiferous tubule degeneration [+]
View all ortholog results at Monarch