| Monarch Ortholog Phenotypes
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Human (8 sources):
Abnormality of neutrophils,
Dilated cardiomyopathy,
EMG abnormality,
Elevated circulating creatine kinase concentration,
Lipoatrophy,
Myopathy,
Palmoplantar keratoderma,
Sensorineural hearing impairment
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Mouse (32 sources):
abnormal axon radial sorting,
abnormal circulating bilirubin level,
abnormal dorsal spinal root morphology,
abnormal myelin sheath morphology,
abnormal myocardial fiber morphology,
abnormal sciatic nerve morphology,
abnormal sinus arrhythmia,
abnormal ventral spinal root morphology,
cardiac hypertrophy,
cardiac interstitial fibrosis,
cardiac ischemia,
decreased Schwann cell number,
decreased erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased ventricle muscle contractility,
dilated capillary,
dilated heart left ventricle,
enlarged myocardial fiber,
hypoxia,
impaired balance,
impaired basement membrane formation,
impaired limb coordination,
impaired swimming,
increased heart weight,
increased sensitivity to induced morbidity/mortality,
increased spleen weight,
limb grasping,
myocardial fiber degeneration,
neonatal lethality, incomplete penetrance,
poor circulation,
shortened RR interval
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.