| Monarch Ortholog Phenotypes
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Human (54 sources):
Abnormal EKG,
Abnormal circulating aldosterone,
Abnormal circulating corticosterone level,
Abnormal sex determination,
Absence of secondary sex characteristics,
Adrenal hyperplasia,
Adrenocorticotropic hormone excess,
Adrenogenital syndrome,
Ambiguous genitalia,
Ambiguous genitalia, male,
Aortic root aneurysm,
Congenital adrenal hyperplasia,
Cryptorchidism,
Decreased circulating androgen concentration,
Decreased circulating cortisol level,
Decreased circulating renin level,
Decreased fertility,
Decreased fertility in females,
Decreased fertility in males,
Decreased serum estradiol,
Decreased serum testosterone concentration,
Decreased testicular size,
Delayed puberty,
Delayed skeletal maturation,
Dysmenorrhea,
Elevated circulating follicle stimulating hormone level,
Elevated circulating luteinizing hormone level,
Enlarged polycystic ovaries,
Failure to thrive,
Female external genitalia in individual with 46,XY karyotype,
Generalized hyperpigmentation,
Gynecomastia,
Hyperaldosteronism,
Hypergonadotropic hypogonadism,
Hypertension,
Hypervolemia,
Hypokalemia,
Hypokalemic alkalosis,
Hypoplasia of the uterus,
Hypoplasia of the vagina,
Hypospadias,
Increased circulating ACTH level,
Male pseudohermaphroditism,
Micropenis,
Osteoporosis,
Polycystic ovaries,
Primary adrenal insufficiency,
Primary amenorrhea,
Primary gonadal insufficiency,
Reduced bone mineral density,
Short stature,
Sparse axillary hair,
Sparse body hair,
Sparse pubic hair
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Mouse (31 sources):
abnormal adipose tissue amount,
abnormal anxiety-related response,
abnormal blood urea nitrogen level,
abnormal bone mineralization,
abnormal circulating cholesterol level,
abnormal circulating phosphate level,
abnormal fasting circulating glucose level,
abnormal grip strength,
abnormal lean body mass,
abnormal locomotor activation,
abnormal sexual interaction,
abnormal sperm flagellum morphology,
abnormal vocalization,
absent external male genitalia,
asthenozoospermia,
decreased bone mineral content,
decreased grip strength,
decreased heart weight,
decreased lean body mass,
decreased locomotor activity,
early reproductive senescence,
embryonic lethality between implantation and somite formation, complete penetrance,
improved glucose tolerance,
increased anxiety-related response,
increased circulating alkaline phosphatase level,
increased circulating creatinine level,
increased fasting circulating glucose level,
increased thigmotaxis,
increased total body fat amount,
reduced male fertility,
transmission ratio distortion
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.