abnormal hematopoietic system physiology, abnormal hepatocyte morphology, abnormal immune system organ morphology, abnormal seminiferous tubule morphology, abnormal sperm number, abnormal thymus morphology, absent bone marrow cell, decreased airway responsiveness, decreased bone marrow cell number, decreased cell proliferation, decreased double-negative T cell number, decreased embryo size, decreased hepatocyte proliferation, decreased immature B cell number, decreased interferon-gamma secretion, decreased interleukin-13 secretion, decreased interleukin-4 secretion, decreased interleukin-5 secretion, decreased litter size, decreased macrophage cell number, decreased pre-B cell number, decreased pro-B cell number, embryonic growth arrest, embryonic lethality between implantation and somite formation, complete penetrance, immune system phenotype, impaired hematopoiesis, increased T cell derived lymphoma incidence, increased cellular sensitivity to gamma-irradiation, increased foot pad pigmentation, increased interleukin-13 secretion, increased interleukin-4 secretion, increased interleukin-5 secretion, increased late pro-B cell number, increased liver adenoma incidence, increased liver tumor incidence, increased lymphoma incidence, increased macrophage cell number, increased tail pigmentation, lethality throughout fetal growth and development, incomplete penetrance, liver hypoplasia, nervous system phenotype, ovary atrophy, postnatal lethality, complete penetrance, premature death, prenatal lethality, complete penetrance, reduced female fertility, spleen hyperplasia