bcor Phenotypes

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Phenotypes

Gene Literature (9)

Nucleotides (202)

Interactants (208)

XB-GENEPAGE-1010840

Gene Symbol: bcor Gene Name: BCL6 corepressor

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal incomplete closing of the choroid fissure (3 sources), abnormal midgut morphology (3 sources), decreased size of the eye (3 sources), abnormally inverted heart (2 sources), abnormally localised retinal pigmented epithelium (2 sources), abnormally localised midgut (1 source), absent eye (1 source), absent midgut (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: bcor assayed (1 source)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
syndromic microphthalmia 2 (10AP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + bcor MO (9 sources), Xtr Wt + bcor MO (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (110 sources): 2-3 toe syndactyly, Abnormal cardiac septum morphology, Abnormal cardiovascular system morphology, Abnormal clavicle morphology, Abnormal palate morphology, Abnormal shoulder morphology, Abnormality of dental morphology, Abnormality of the dentition, Adrenal insufficiency, Ankyloblepharon, Anophthalmia, Anteverted ears, Aortic valve stenosis, Aplasia/Hypoplasia of the corpus callosum, Asymmetry of the ears, Atrial septal defect, Bifid nasal tip, Bifid uvula, Blepharophimosis, Broad nasal tip, Broad palm, Camptodactyly of finger, Cataract, Chorioretinal coloboma, Cleft palate, Clinodactyly of the 5th finger, Complete duplication of thumb phalanx, Cryptorchidism, Cubitus valgus, Decreased body weight, Delayed eruption of teeth, Dental malocclusion, Developmental cataract, Dextrocardia, Double outlet right ventricle, Ectopia lentis, Exotropia, Feeding difficulties in infancy, Finger syndactyly, Flexion contracture, Flexion contracture of the 2nd toe, Flexion contracture of the 4th toe, Fused teeth, Genu valgum, Glaucoma, Global developmental delay, Hammertoe, Hand clenching, Hearing impairment, Highly arched eyebrow, Hydronephrosis, Hydroureter, Hyperlordosis, Hypoplasia of the corpus callosum, Hypospadias, Hypothyroidism, Intellectual disability, Intellectual disability, mild, Intestinal malrotation, Iris coloboma, Kyphosis, Laterally curved eyebrow, Long face, Long philtrum, Long thorax, Low-set, posteriorly rotated ears, Microcephaly, Microcornea, Microphthalmia, Mitral valve prolapse, Motor delay, Narrow face, Neurological speech impairment, Nystagmus, Oligodontia, Optic disc coloboma, Orofacial cleft, Patent ductus arteriosus, Peripheral pulmonary artery stenosis, Persistence of primary teeth, Phthisis bulbi, Posteriorly rotated ears, Preauricular skin tag, Prominent nasal bridge, Ptosis, Pulmonic stenosis, Radioulnar synostosis, Remnants of the hyaloid vascular system, Renal hypoplasia/aplasia, Retinal detachment, Scoliosis, Seizure, Self-injurious behavior, Sensorineural hearing impairment, Septate vagina, Short stature, Short thumb, Solitary median maxillary central incisor, Spastic paraparesis, Submucous cleft hard palate, Supernumerary tooth, Talipes equinovarus, Thick eyebrow, Tooth malposition, Umbilical hernia, Ventricular septal defect, Visual impairment, Visual loss, Webbed neck, obsolete External ear malformation [+]
Mouse (11 sources): abnormal bone marrow cell physiology, abnormal developmental patterning, abnormal embryo turning, abnormal forebrain development, abnormal gastrulation, abnormal heart looping, embryonic lethality during organogenesis, complete penetrance, failure of heart looping, incomplete somite formation, increased cell proliferation, increased neutrophil cell number [+]
View all ortholog results at Monarch