| Monarch Ortholog Phenotypes
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Human (12 sources):
Adrenal insufficiency,
Failure to thrive,
Global developmental delay,
Hepatomegaly,
Intrauterine growth retardation,
Lymphadenopathy,
Lymphoproliferative disorder,
Microcephaly,
Recurrent respiratory infections,
Recurrent viral infections,
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Mouse (33 sources):
abnormal cell nucleus morphology,
abnormal digestive system development,
abnormal embryo size,
abnormal pericardium morphology,
absent inner cell mass proliferation,
chromosomal instability,
decreased DN1 thymic pro-T cell number,
decreased cell proliferation,
decreased fibroblast proliferation,
embryonic growth retardation,
embryonic lethality between implantation and somite formation, complete penetrance,
embryonic lethality prior to organogenesis,
embryonic lethality prior to tooth bud stage,
embryonic lethality, complete penetrance,
enlarged lymph nodes,
fetal growth retardation,
increased T cell derived lymphoma incidence,
increased acute lymphoblastic leukemia incidence,
increased grip strength,
increased hepatocellular carcinoma incidence,
increased lymphoma incidence,
increased mammary adenocarcinoma incidence,
increased mammary gland tumor incidence,
increased tumor incidence,
induced chromosome breakage,
lethality throughout fetal growth and development, complete penetrance,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance,
premature death,
prenatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
spontaneous chromosome breakage
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.