hgs Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-1016032

Gene Symbol: hgs Gene Name: hepatocyte growth factor-regulated tyrosine kinase substrate

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: hgs assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (54 sources): Purkinje cell degeneration, abnormal CNS glial cell morphology, abnormal axon morphology, abnormal brain development, abnormal cerebellar cortex morphology, abnormal coping response, abnormal embryonic tissue morphology, abnormal extraembryonic tissue morphology, abnormal hippocampus pyramidal cell morphology, abnormal medulla oblongata morphology, abnormal myelin sheath morphology, abnormal resting posture, abnormal rostral-caudal axis patterning, abnormal somite development, abnormal spinal cord grey matter morphology, abnormal spinal cord white matter morphology, abnormal spinal nerve morphology, abnormal total retina thickness, abnormal vertebral column morphology, abnormal vertebral spinous process morphology, absent foregut, axonal dystrophy, behavioral despair, cardia bifida, decreased body size, decreased corticospinal tract size, decreased embryo size, decreased hindbrain size, decreased midbrain size, decreased neuron number, decreased pons size, decreased spinal cord size, decreased total retina thickness, decreased trabecular bone thickness, decreased vertical activity, dilated allantois, embryonic lethality between implantation and somite formation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, failure of chorioallantoic fusion, failure of initiation of embryo turning, hearing/vestibular/ear phenotype, impaired balance, impaired passive avoidance behavior, impaired swimming, increased neuron apoptosis, muscular atrophy, open neural tube, premature death, short vertebral body, slow postnatal weight gain, small cerebellum, thin cerebellar granule layer, wavy neural tube [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (54 sources): Purkinje cell degeneration, abnormal CNS glial cell morphology, abnormal axon morphology, abnormal brain development, abnormal cerebellar cortex morphology, abnormal coping response, abnormal embryonic tissue morphology, abnormal extraembryonic tissue morphology, abnormal hippocampus pyramidal cell morphology, abnormal medulla oblongata morphology, [+]