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Summary Expression Phenotypes Gene Literature (57) GO Terms (11) Nucleotides (61) Proteins (32) Interactants (487) Wiki

ascl1     achaete-scute family bHLH transcription factor 1

Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ascl1 manipulated (11 sources), ascl1 assayed (4 sources)
Computed annotations: ascl1 manipulated (1 source), ascl1 assayed (19 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ascl1 (4 sources), Xla Wt + Mmu.ascl1 (2 sources), Xla Wt + ascl1 MO (1 source), Xla Wt + Mmu.ascl1 + ccna2 + cdk2 (1 source), Xla Wt + Mmu.ascl1 + mycn (1 source), Xla Wt + Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A (1 source), Xla Wt + Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A + ccna2 + cdk2 (1 source), Xla Wt + Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A + mycn (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (37 sources): Abnormal autonomic nervous system physiology, Abnormality of temperature regulation, Abnormality of the autonomic nervous system, Abnormality of the cardiovascular system, Abnormality of the mouth, Abnormality of the nervous system, Aganglionic megacolon, Apnea, Breathing dysregulation, Central hypoventilation, [+]
Mouse (21 sources): abnormal enteric neuron morphology, abnormal horizontal basal cell of olfactory epithelium morphology, abnormal lung development, abnormal nervous system development, abnormal neuron apoptosis, abnormal olfactory epithelium morphology, abnormal olfactory sensory neuron morphology, abnormal parasympathetic ganglion morphology, abnormal spinal cord interneuron morphology, abnormal sympathetic ganglion morphology, [+]

View all ortholog results at Monarch