ccdc88c Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1033685

Gene Symbol: ccdc88c Gene Name: coiled-coil domain containing 88C

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
obsolete duplicated anterior-posterior axis (11 sources), decreased length of anterior-posterior axis (8 sources), abnormal bending of dorsal trunk (7 sources), abnormal gastrulation (5 sources), abnormal bending of tail (4 sources), wholly anteriorized embryo (3 sources), abnormal incomplete closing of the neural tube (2 sources), decreased length of dorsal-ventral axis (2 sources), decreased length of whole organism (2 sources), decreased size of the head (2 sources), abnormally localised muscle (1 source), decreased size of the tail (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

obsolete duplicated anterior-posterior axis (11 sources), decreased length of anterior-posterior axis (8 sources), abnormal bending of dorsal trunk (7 sources), abnormal gastrulation (5 sources), abnormal bending of tail (4 sources), wholly anteriorized embryo (3 sources), abnormal incomplete closing of the neural tube (2 sources), decreased length of dorsal-ventral axis (2 sources), decreased length of whole organism (2 sources), decreased size of the head (2 sources), abnormally localised muscle (1 source), decreased size of the tail (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ccdc88c assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ccdc88c (4 sources), Xla Wt + ccdc88c (2 sources), Xla Wt + ccdc88cdel_1-1151 (2 sources), Xla Wt + ccdc88cdel_1-1229 (2 sources), Xla Wt + ccdc88cdel_1301-1559 (2 sources), Xla Wt + ccdc88cdel_772-1261 (2 sources), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c MO (1 source), Xla Wt + ctnnb1 + ccdc88c MO (1 source), Xla Wt + dvl1 + myc-Mmu.ccdc88c (1 source), Xla Wt + myc-Mmu.ccdc88c (1 source), Xla Wt + myc-Mmu.ccdc88c (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + ccdc88c (4 sources), Xla Wt + ccdc88c (2 sources), Xla Wt + ccdc88cdel_1-1151 (2 sources), Xla Wt + ccdc88cdel_1-1229 (2 sources), Xla Wt + ccdc88cdel_1301-1559 (2 sources), Xla Wt + ccdc88cdel_772-1261 (2 sources), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c MO (1 source), Xla Wt + ctnnb1 + ccdc88c MO (1 source), Xla Wt + dvl1 + myc-Mmu.ccdc88c (1 source), Xla Wt + myc-Mmu.ccdc88c (1 source), Xla Wt + myc-Mmu.ccdc88c (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (18 sources): Broad-based gait, Dysarthria, Dysdiadochokinesis, Dysmetria, Functional motor deficit, Gait ataxia, Hydrocephalus, Hyperreflexia, Intellectual disability, Intention tremor, Neurological speech impairment, Pontocerebellar atrophy, Scanning speech, Seizure, Spastic paraparesis, Unsteady gait, Ventriculomegaly, Vertical supranuclear gaze palsy [+]
Mouse (3 sources): abnormal brain ependyma morphology, abnormal brain ependyma motile cilium location or orientation, impaired wound healing
View all ortholog results at Monarch