invs Phenotypes

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Phenotypes

Gene Literature (17)

Nucleotides (59)

Interactants (188)

XB-GENEPAGE-1221136

Gene Symbol: invs Gene Name: inversin

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of pronephric kidney (2 sources), abnormal pronephric tubule morphology (2 sources), abnormal development of distal tubule (1 source), abnormal development of proximal tubule (1 source), abnormal pronephric kidney morphology (1 source), decreased size of the distal tubule (1 source), decreased size of the pronephric kidney (1 source), edematous embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: invs assayed (6 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
nephronophthisis 2 (9AP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + invs MO (9 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (37 sources): Abnormality of bone mineral density, Abnormality of retinal pigmentation, Absence of renal corticomedullary differentiation, Aortic valve stenosis, Ataxia, Cataract, Cholestasis, Chronic kidney disease, Chronic tubulointerstitial nephritis, Cone-shaped epiphysis, Congenital hepatic fibrosis, Elevated circulating creatinine concentration, Enlarged kidney, Global developmental delay, Hepatic fibrosis, Hyperechogenic kidneys, Hyperkalemia, Hyperkalemic metabolic acidosis, Hypertension, Hypertrophic cardiomyopathy, Nephronophthisis, Oligohydramnios, Patent ductus arteriosus, Polycystic kidney dysplasia, Premature ovarian insufficiency, Progressive visual loss, Pulmonary hypoplasia, Pulmonary insufficiency, Pulmonic stenosis, Renal cortical microcysts, Renal insufficiency, Respiratory insufficiency, Retinal dystrophy, Short stature, Situs inversus totalis, Stage 5 chronic kidney disease, Visual impairment [+]
Mouse (40 sources): abdominal situs ambiguus, abnormal atrioventricular cushion morphology, abnormal direction of embryo turning, abnormal direction of heart looping, abnormal embryonic cilium location or orientation, abnormal kidney interstitium morphology, abnormal kidney morphology, abnormal kidney pelvis morphology, abnormal loop of Henle ascending limb thick segment morphology, abnormal loop of Henle descending limb morphology, abnormal motile primary cilium physiology, abnormal pancreatic acinar cell morphology, abnormal pancreatic acinus morphology, abnormal pancreatic islet morphology, abnormal primitive node morphology, abnormal renal glomerulus morphology, aorta hypoplasia, decreased body size, decreased pancreatic acinar cell number, dilated kidney collecting duct, dilated pancreatic duct, dilated proximal convoluted tubule, dilated renal tubules, disorganized pancreatic islets, increased glomerular capsule space, increased kidney weight, kidney medulla cyst, left pulmonary isomerism, left-sided isomerism, pancreatic islet hyperplasia, postnatal lethality, proximal convoluted tubule brush border loss, renal glomerulus cyst, renal/urinary system phenotype, respiratory system phenotype, right pulmonary isomerism, right-sided stomach, situs ambiguus, situs inversus, slow postnatal weight gain [+]
View all ortholog results at Monarch