gata2 Phenotypes

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Phenotypes

Gene Literature (80)

Nucleotides (408)

Interactants (958)

XB-GENEPAGE-478164

Gene Symbol: gata2 Gene Name: GATA binding protein 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased width of neural plate (5 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: gata2 manipulated (42 sources), gata2 assayed (3 sources)
Computed annotations: gata2 assayed (30 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + gata2 (13 sources), Xla Wt + gata2 MO (13 sources), Xla Wt + gata2del-EnR (13 sources), Xla Wt + gata2 MO (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (47 sources): Abnormal natural killer cell morphology, Abnormal neutrophil count, Abnormality of the optic nerve, Acute leukemia, Aplastic anemia, Arachnodactyly, Bone marrow hypocellularity, Bruising susceptibility, Cellulitis, Chronic otitis media, Epicanthus, Fatigue, Fever, Hepatomegaly, Hypercoagulability, Hypotelorism, Immunodeficiency, Intracranial hemorrhage, Leukemia, Leukocytosis, Lymphadenopathy, Lymphedema, Lymphopenia, Migraine, Monocytopenia, Myelodysplasia, Myeloid leukemia, Myeloproliferative disorder, Nausea and vomiting, Neurological speech impairment, Neutropenia, Pallor, Pancytopenia, Prolonged bleeding time, Recurrent fungal infections, Recurrent mycobacterium avium complex infections, Recurrent respiratory infections, Recurrent viral infections, Respiratory insufficiency, Sensorineural hearing impairment, Splenomegaly, Tapered finger, Thrombocytopenia, Vertigo, Visual loss, Webbed neck, Weight loss [+]
Mouse (51 sources): abnormal GABAergic neuron morphology, abnormal blood cell morphology/development, abnormal blood urea nitrogen level, abnormal blood vessel endothelium morphology, abnormal chorioallantoic fusion, abnormal definitive hematopoiesis, abnormal embryo size, abnormal embryonic hematopoiesis, abnormal epididymis morphology, abnormal erythropoiesis, abnormal forebrain development, abnormal hindbrain development, abnormal kidney morphology, abnormal megakaryocyte progenitor cell morphology, abnormal midbrain development, abnormal neuron differentiation, abnormal pituitary gland development, abnormal pituitary secretion, abnormal renal/urinary system morphology, abnormal serotonergic neuron morphology, abnormal ureter development, absent epididymis, absent vitelline blood vessels, decreased blood urea nitrogen level, decreased body size, decreased circulating thyroid-stimulating hormone level, decreased common myeloid progenitor cell number, decreased hematopoietic stem cell number, decreased seminal vesicle weight, decreased survivor rate, embryonic lethality, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, enlarged epididymis, enlarged pericardium, hearing/vestibular/ear phenotype, hematopoietic system phenotype, impaired hematopoiesis, increased prepulse inhibition, increased vascular permeability, large ureter, lethality throughout fetal growth and development, incomplete penetrance, liver hypoplasia, nervous system phenotype, no abnormal phenotype detected, pale yolk sac, perinatal lethality, incomplete penetrance, postnatal lethality, incomplete penetrance, premature death, preweaning lethality, complete penetrance, small liver [+]
View all ortholog results at Monarch