| Monarch Ortholog Phenotypes
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Human (12 sources):
Blindness,
Exudative vitreoretinopathy,
Falciform retinal fold,
Peripheral retinal avascularization,
Posterior vitreous detachment,
Recurrent fractures,
Reduced visual acuity,
Retinal detachment,
Retinal exudate,
Retinal neovascularization,
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Mouse (40 sources):
abnormal astrocyte physiology,
abnormal brain vasculature morphology,
abnormal cerebellar granule layer morphology,
abnormal corpus luteum morphology,
abnormal digestion,
abnormal embryo size,
abnormal esophageal squamous epithelium morphology,
abnormal eye electrophysiology,
abnormal optokinetic reflex,
abnormal organ of Corti morphology,
abnormal retina vasculature morphology,
abnormal stria vascularis morphology,
abnormal stria vascularis vasculature morphology,
abnormal vascular development,
absent corpus luteum,
absent startle reflex,
cardiovascular system phenotype,
cochlear hair cell degeneration,
cochlear inner hair cell degeneration,
cochlear outer hair cell degeneration,
decreased Purkinje cell number,
decreased angiogenesis,
decreased circulating progesterone level,
decreased skeletal muscle fiber diameter,
decreased startle reflex,
diluted coat color,
enlarged esophagus,
failure of embryo implantation,
hunched posture,
impaired luteal cell differentiation,
impaired luteinization,
increased or absent threshold for auditory brainstem response,
no abnormal phenotype detected,
persistence of hyaloid vascular system,
premature death,
renal/urinary system phenotype,
reproductive system phenotype,
short stride length,
small kidney,
stria vascularis degeneration
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.