tcf3 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (160)

XB-GENEPAGE-478264

Gene Symbol: tcf3 Gene Name: transcription factor 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally ventralized embryo (2 sources), abnormal foregut epithelium morphology (1 source), abnormal liver morphology (1 source), abnormally dorsalized embryo (1 source), decreased size of the liver primordium (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tcf3 manipulated (12 sources)
Computed annotations: tcf3 manipulated (1 source), tcf3 assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dntcf3-GR + sfrp5 MO + DEX (2 sources), Xla Wt + nodal1 + dntcf3 (1 source), Xla Wt + sox17b.2 + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 MO (1 source), Xla Wt + dntcf3 (1 source), Xla Wt + dntcf3 (1 source), Xla Wt + dntcf3-GR (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xtr Wt + tcf3 MO (1 source), Xtr Wt + dntcf3-GR + DEX (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + dntcf3-GR + sfrp5 MO + DEX (2 sources), Xla Wt + nodal1 + dntcf3 (1 source), Xla Wt + sox17b.2 + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 (1 source), Xla Wt + tcf3 MO (1 source), Xla Wt + dntcf3 (1 source), Xla Wt + dntcf3 (1 source), Xla Wt + dntcf3-GR (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xla Wt + dntcf3-GR + DEX (1 source), Xtr Wt + tcf3 MO (1 source), Xtr Wt + dntcf3-GR + DEX (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (31 sources): Agammaglobulinemia, Arthritis, B lymphocytopenia, Bronchiectasis, Cellulitis, Chronic otitis media, Conjunctivitis, Cough, Dehydration, Diarrhea, Epicanthus, Failure to thrive, Fatigue, Fever, Hepatitis, High palate, Hypertelorism, Immunodeficiency, Malabsorption, Meningitis, Neutropenia, Osteomyelitis, Recurrent infections, Recurrent otitis media, Recurrent respiratory infections, Recurrent skin infections, Sepsis, Sinusitis, Skin rash, Verrucae, obsolete External ear malformation [+]
Mouse (27 sources): abnormal brain development, abnormal eyelid development, abnormal foregut morphology, abnormal limb bud morphology, abnormal limb development, abnormal neural fold formation, abnormal notochord morphology, abnormal primitive streak formation, abnormal rostral-caudal axis patterning, absent heart, absent somites, decreased embryo size, decreased forebrain size, digestive/alimentary phenotype, dilated vasculature, embryonic lethality during organogenesis, complete penetrance, enlarged pericardium, eyelids open at birth, failure of eyelid fusion, increased axial mesoderm size, increased somite number, lethality throughout fetal growth and development, incomplete penetrance, neonatal lethality, complete penetrance, no abnormal phenotype detected, rostral body truncation, rostral-caudal axis duplication, small embryonic telencephalon [+]
View all ortholog results at Monarch