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XB-GENEPAGE-478698
fgfr4 fibroblast growth factor receptor 4
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| abnormal alimentary system morphology (3 sources), abnormal gastrocoel roof plate morphology (3 sources), abnormal heart looping (3 sources), abnormal left-right organizer morphology (3 sources), abnormal bending of tail (2 sources), abnormal development of embryo (2 sources), abnormal tail morphology (2 sources), abnormally decreased number of cilium in the left-right organizer (2 sources), decreased length of tail (2 sources), decreased size of the head (2 sources), decreased size of the presomitic mesoderm (1 source), increased size of the head (1 source), tail abnormally curved dorsally (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: fgfr4 manipulated (13 sources) |
| Computed annotations: fgfr4 assayed (2 sources) |
| Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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| congenital heart disease (6AP sources, 13 EP sources), visceral heterotaxy (6AP sources, 13 EP sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xtr Wt + fgfr4 CRISPR (14 sources), Xtr Wt + fgfr4 MO (2 sources), Xtr Wt + fgfr4 MO (2 sources), Xla Wt + Cco.FGFR4del-Hsa.IGHG3del (1 source), Xtr Wt + fgfr4 CRISPR (1 source), Xtr Wt + fgfr4 CRISPR (1 source), Xtr Wt + fgfr4 CRISPR (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Mouse (6 sources): abnormal bone mineralization, abnormal eye anterior chamber depth, cellular phenotype, decreased B-1a cell number, decreased bone mineral content, increased body length |