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XB-GENEPAGE-479045
smurf1 SMAD specific E3 ubiquitin protein ligase 1
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| decreased length of anterior-posterior axis (6 sources), decreased size of the head (4 sources), abnormal eye morphology (3 sources), increased size of the cement gland (3 sources), abnormal incomplete closing of the neural tube (2 sources), abnormally localised cement gland (2 sources), decreased size of the eye (2 sources), abnormal anterior-posterior axis morphology (1 source), abnormal bending of anterior neural tube (1 source), abnormal bending of anterior-posterior axis (1 source), decreased size of the anterior-posterior axis (1 source), decreased size of the tail (1 source), duplicated dorsal trunk (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: smurf1 manipulated (8 sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xla Wt + smurf1 MO (3 sources), Xla Wt + smurf1 (2 sources), Xla Wt + smurf1 (2 sources), Xla Wt + smurf1 + smurf2 (2 sources), Xla Wt + smurf1 MO (2 sources), Xla Wt + smurf1 (1 source), Xla Wt + smurf1 + smurf2 (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Mouse (6 sources): abnormal osteoblast physiology, decreased cardiac stroke volume, increased compact bone thickness, increased trabecular bone mass, no abnormal phenotype detected, trunk curl |