| Monarch Ortholog Phenotypes
|
Human (39 sources):
Abnormal autonomic nervous system physiology,
Abnormal renal physiology,
Amyloid deposition in the vitreous humor,
Amyloidosis,
Arrhythmia,
Ataxia,
Atrioventricular block,
Cardiomegaly,
Cardiomyopathy,
Constipation,
Constrictive median neuropathy,
Dementia,
Diarrhea,
Digital flexor tenosynovitis,
Dysarthria,
Headache,
Hearing impairment,
Hemiparesis,
Hyporeflexia,
Impotence,
Increased CSF protein,
Leptomeningeal enhancement,
Muscle weakness,
Nephropathy,
Nystagmus,
Orthostatic hypotension due to autonomic dysfunction,
Paraplegia,
Peripheral axonal neuropathy,
Peripheral neuropathy,
Polyneuropathy,
Reduced circulating vitamin B6 circulating,
Seizure,
Spasticity,
Stroke-like episode,
Tremor,
Urinary incontinence,
Visual impairment,
Vitreous floaters,
Weight loss
[+]
|
|
Mouse (8 sources):
abnormal blood homeostasis,
abnormal retinol level,
abnormal retinol metabolism,
decreased circulating levels of thyroid hormone,
decreased circulating thyroxine level,
opacity of vitreous body,
vision/eye phenotype,
vitreous body deposition
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.