nr4a2 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (11)

XB-GENEPAGE-480892

Gene Symbol: nr4a2 Gene Name: nuclear receptor subfamily 4 group A member 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: nr4a2 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (41 sources): abnormal T-helper 1 cell differentiation, abnormal T-helper 17 cell differentiation, abnormal dopamine level, abnormal dopaminergic neuron morphology, abnormal locomotor activation, abnormal midbrain development, abnormal motor capabilities/coordination/movement, abnormal nervous system development, abnormal noradrenaline level, abnormal regulatory T cell morphology, abnormal regulatory T cell physiology, abnormal response/metabolism to endogenous compounds, abnormal serotonin level, abnormal substantia nigra morphology, abnormal suckling behavior, abnormal tegmentum morphology, behavioral despair, decreased body size, decreased dopamine level, decreased dopaminergic neuron number, decreased locomotor activity, decreased noradrenaline level, decreased regulatory T cell number, decreased vertical activity, enhanced behavioral response to addictive substance, enhanced behavioral response to xenobiotic, immune system phenotype, impaired passive avoidance behavior, impaired righting response, increased CD4-positive, alpha beta T cell number, increased T-helper 1 cell number, increased midbrain apoptosis, increased serotonin level, increased susceptibility to induced colitis, increased susceptibility to weight loss, lethality at weaning, complete penetrance, loss of dopaminergic neurons, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, nervous system phenotype, neuron degeneration [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (41 sources): abnormal T-helper 1 cell differentiation, abnormal T-helper 17 cell differentiation, abnormal dopamine level, abnormal dopaminergic neuron morphology, abnormal locomotor activation, abnormal midbrain development, abnormal motor capabilities/coordination/movement, abnormal nervous system development, abnormal noradrenaline level, abnormal regulatory T cell morphology, [+]