isl1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (110)

XB-GENEPAGE-481335

Gene Symbol: isl1 Gene Name: ISL LIM homeobox 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: isl1 assayed (10 sources)
Computed annotations: isl1 assayed (8 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (51 sources): abnormal Rathke's pouch development, abnormal auditory bulla morphology, abnormal dorsal aorta morphology, abnormal heart development, abnormal heart shape, abnormal hindlimb bud morphology, abnormal hindlimb zeugopod morphology, abnormal ischium morphology, abnormal malleus morphology, abnormal optic nerve innervation, abnormal optic tract morphology, abnormal pancreas mesenchyme morphology, abnormal pancreatic acinar cell morphology, abnormal pancreatic islet morphology, abnormal retina bipolar cell morphology, abnormal retina ganglion cell morphology, abnormal retina outer plexiform layer morphology, abnormal sensory neuron morphology, abnormal spinal cord interneuron morphology, abnormal splanchnic mesoderm morphology, abnormal tympanic membrane morphology, abnormal vascular endothelial cell morphology, absent cardiac outflow tract, absent heart right ventricle, absent hindlimb, absent pancreatic alpha cells, absent pinna reflex, decreased amacrine cell number, decreased embryo size, decreased embryonic neuroepithelium thickness, decreased retina ganglion cell number, decreased retina inner nuclear layer thickness, embryo tissue necrosis, embryonic growth arrest, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, excessive cerumen, failure of heart looping, hearing/vestibular/ear phenotype, increased or absent threshold for auditory brainstem response, increased retina apoptosis, increased susceptibility to otitis media, middle ear effusion, no abnormal phenotype detected, optic nerve degeneration, perinatal lethality, complete penetrance, preweaning lethality, complete penetrance, retina ganglion cell degeneration, small Rathke's pouch, thin retina inner plexiform layer, vision/eye phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (51 sources): abnormal Rathke's pouch development, abnormal auditory bulla morphology, abnormal dorsal aorta morphology, abnormal heart development, abnormal heart shape, abnormal hindlimb bud morphology, abnormal hindlimb zeugopod morphology, abnormal ischium morphology, abnormal malleus morphology, abnormal optic nerve innervation, [+]