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Summary Expression Phenotypes Gene Literature (191) GO Terms (5) Nucleotides (126) Proteins (43) Interactants (1246) Wiki
XB-GENEPAGE-481643

dkk1     dickkopf WNT signaling pathway inhibitor 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased size of the head (4 sources), decreased length of anterior-posterior axis (2 sources), increased size of the foregut (2 sources), obsolete abnormal histone phosphorylation (2 sources), abnormal bending of tail (1 source), abnormal cilium assembly (1 source), abnormal development of hindgut (1 source), abnormal foregut epithelium morphology (1 source), abnormally decreased length of hindgut (1 source), abnormally decreased number of cilium in the multiciliated cell (1 source), abnormally decreased number of small secretory cell (1 source), absent head (1 source), decreased size of the cilium in the multiciliated epidermal cell (1 source), increased size of the cement gland (1 source), increased size of the dorsal pancreatic bud (1 source), increased size of the liver (1 source), increased size of the ventral pancreatic bud (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dkk1 manipulated (6 sources), dkk1 assayed (13 sources)
Computed annotations: dkk1 assayed (36 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dkk1 (3 sources), Xla Wt + Hsa.DKK1 (3 sources), Xla Wt + dkk1 (2 sources), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 + sfrp5 MO (1 source), Xtr Wt + dkk1 (1 source), Xtr Wt + dkk1 (1 source), Xtr Wt + dkk1 + ventral marginal zone explant (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (52 sources): Abnormality of the clivus, Abnormality of the eleventh cranial nerve, Abnormality of the musculature of the lower limbs, Abnormality of the twelfth cranial nerve, Abnormality of the vestibulocochlear nerve, Adult onset sensorineural hearing impairment, Anteriorly placed odontoid process, Areflexia of upper limbs, Babinski sign, Basilar impression, [+]
Mouse (52 sources): abnormal anterior head development, abnormal bone mineralization, abnormal craniofacial development, abnormal definitive hematopoiesis, abnormal embryonic neuroepithelium morphology, abnormal first pharyngeal arch morphology, abnormal forelimb morphology, abnormal hematopoietic stem cell physiology, abnormal hindlimb morphology, abnormal kidney collecting duct epithelium morphology, [+]

View all ortholog results at Monarch