spry2 Phenotypes

Phenotypes

XB-GENEPAGE-482100

Gene Symbol: spry2 Gene Name: sprouty RTK signaling antagonist 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration (5 sources), abnormal retina (5 sources), abnormally decreased number of retinal progenitor cell (3 sources), increased MAP kinase activity (2 sources), abnormal cell division (1 source), abnormal protein phosphorylation (1 source), decreased MAP kinase activity (1 source), decreased size of the eye (1 source), increased size of the proliferative region (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: spry2 manipulated (1 source), spry2 assayed (3 sources)
Computed annotations: spry2 assayed (15 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
microphthalmia (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + spry2 MO (7 sources), Xla Wt + spry2 (2 sources), Xla Wt + spry2 MO (1 source), Xla Wt + spry2dn (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (23 sources): abnormal Claudius cell morphology, abnormal auditory brainstem response waveform shape, abnormal cardiac epithelial to mesenchymal transition, abnormal cardiac outflow tract development, abnormal diastema morphology, abnormal enteric neuron morphology, abnormal heart development, abnormal molar cusp morphology, abnormal organ of Corti morphology, abnormal organ of Corti supporting cell morphology, abnormal pillar cell morphology, abnormal tooth development, atrioventricular septal defect, cardiovascular system phenotype, decreased body size, dilated esophagus, increased Deiters cell number, increased cochlear outer hair cell number, increased lung tumor incidence, increased or absent threshold for auditory brainstem response, postnatal lethality, incomplete penetrance, premature death, short mandible [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (23 sources): abnormal Claudius cell morphology, abnormal auditory brainstem response waveform shape, abnormal cardiac epithelial to mesenchymal transition, abnormal cardiac outflow tract development, abnormal diastema morphology, abnormal enteric neuron morphology, abnormal heart development, abnormal molar cusp morphology, abnormal organ of Corti morphology, abnormal organ of Corti supporting cell morphology, [+]