| Monarch Ortholog Phenotypes
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Human (1 source):
Eczematoid dermatitis
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Mouse (33 sources):
abnormal T-helper 2 cell morphology,
abnormal T-helper 2 physiology,
abnormal bronchus morphology,
abnormal circulating cytokine level,
abnormal circulating interferon-gamma level,
abnormal crypts of Lieberkuhn morphology,
abnormal intestinal epithelium morphology,
abnormal intestinal goblet cell morphology,
abnormal macrophage activation involved in immune response,
abnormal macrophage physiology,
abnormal microglial cell morphology,
abnormal susceptibility to infection,
decreased IgG1 level,
decreased T cell proliferation,
decreased T-helper 2 cell number,
decreased core body temperature,
decreased fatty acids level,
decreased interleukin-10 secretion,
decreased interleukin-4 secretion,
decreased interleukin-5 secretion,
decreased susceptibility to parasitic infection,
granulomatous inflammation,
impaired macrophage chemotaxis,
increased IgG2a level,
increased airway responsiveness,
increased circulating interleukin-4 level,
increased interleukin-4 secretion,
increased respiratory mucosa goblet cell number,
increased susceptibility to parasitic infection,
increased susceptibility to type I hypersensitivity reaction,
increased transforming growth factor beta level,
premature death,
respiratory system inflammation
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.