pdx1 Phenotypes

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Phenotypes

Gene Literature (82)

Nucleotides (60)

Interactants (422)

XB-GENEPAGE-483330

Gene Symbol: pdx1 Gene Name: pancreatic and duodenal homeobox 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased size of the pancreas (2 sources), abnormal bending of tail (1 source), abnormal dorsal fin margin morphology (1 source), abnormal duodenum morphology (1 source), abnormal stomach morphology (1 source), abnormal ventral fin margin morphology (1 source), decreased size of the duodenum (1 source), decreased size of the stomach (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: pdx1 manipulated (4 sources), pdx1 assayed (35 sources)
Computed annotations: pdx1 assayed (5 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + pdx1-GR + ptf1a-GR + DEX (4 sources), Xla Wt + pdx1 MO (1 source), Xla Wt + pdx1 MO + ptf1a MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (73 sources): Abnormal C-peptide level, Abnormal heart morphology, Abnormal insulin level, Abnormal oral glucose tolerance, Abnormality of the ear, Abnormality of the genitourinary system, Abnormality of the immune system, Abnormality of the kidney, Abnormality of the upper urinary tract, Anteverted nares, Apraxia, Arthrogryposis multiplex congenita, Ataxia, Axial hypotonia, Beta-cell dysfunction, Bilateral ptosis, Bilateral tonic-clonic seizure, Clinodactyly, Coma, Contractures of the joints of the lower limbs, Dehydration, Diabetes mellitus, Downturned corners of mouth, Elevated hemoglobin A1c, Exocrine pancreatic insufficiency, Failure to thrive, Generalized myoclonic seizure, Global developmental delay, Glucose intolerance, Glycosuria, Hearing impairment, Hepatocellular adenoma, Hyperglycemia, Hyperinsulinemic hypoglycemia, Hypoinsulinemia, Hypotonia, Hypovolemia, Hypsarrhythmia, Insulin-resistant diabetes mellitus, Intellectual disability, Intellectual disability, severe, Intrauterine growth retardation, Ketoacidosis, Ketonuria, Large for gestational age, Limb joint contracture, Long philtrum, Maturity-onset diabetes of the young, Moderate albuminuria, Motor delay, Muscle weakness, Neonatal hypoglycemia, Neonatal insulin-dependent diabetes mellitus, Nephropathy, Neurodevelopmental delay, Obesity, Overweight, Pancreatic hypoplasia, Peripheral axonal neuropathy, Peripheral neuropathy, Prominent metopic ridge, Ptosis, Radial deviation of finger, Reduced pancreatic beta cells, Renal cyst, Renal tubular dysfunction, Retinopathy, Seizure, Short nose, Small for gestational age, Transient neonatal diabetes mellitus, Type II diabetes mellitus, Weight loss [+]
Mouse (52 sources): abnormal PP cell morphology, abnormal bile duct development, abnormal duodenum morphology, abnormal embryo size, abnormal enteroendocrine cell morphology, abnormal foregut morphology, abnormal liver development, abnormal mitochondrial physiology, abnormal pancreas development, abnormal pancreatic acinar cell morphology, abnormal pancreatic beta cell apoptosis, abnormal pancreatic beta cell differentiation, abnormal pancreatic beta cell physiology, abnormal pancreatic delta cell morphology, abnormal pancreatic duct morphology, abnormal pancreatic endocrine progenitor cell physiology, abnormal pancreatic epsilon cell morphology, abnormal pancreatic islet cell apoptosis, abnormal pancreatic islet morphology, abnormal pancreatic islet size, abnormal pyloric sphincter morphology, abnormal small intestine placement, abnormal stomach enteroendocrine cell morphology, abnormal stomach pyloric region morphology, absent Brunner's glands, decreased amylin secretion, decreased body size, decreased insulin secretion, decreased pancreas weight, decreased pancreatic alpha cell mass, decreased pancreatic beta cell mass, decreased pancreatic beta cell proliferation, decreased pancreatic islet number, disorganized pancreatic islets, distended stomach, endocrine/exocrine gland phenotype, homeostasis/metabolism phenotype, immune system phenotype, increased PP cell number, increased circulating glucose level, increased glucagon secretion, increased pancreatic alpha cell number, increased pancreatic alpha cell proliferation, increased pancreatic beta cell apoptosis, increased pancreatic delta cell number, liver/biliary system phenotype, no abnormal phenotype detected, pancreatic islet hypoplasia, postnatal lethality, complete penetrance, preweaning lethality, complete penetrance, small pancreas, small pancreatic islets [+]
View all ortholog results at Monarch