| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormal female external genitalia morphology,
Abnormal peripheral myelination,
Abnormal vagina morphology,
Abnormality of peripheral nerve conduction,
Abnormality of peripheral nerves,
Abnormality of the epididymis,
Decreased number of peripheral myelinated nerve fibers,
Decreased serum estradiol,
Decreased serum testosterone concentration,
Distal muscle weakness,
Gonadal dysgenesis,
Gonadal dysgenesis with female appearance, male,
Gonadal dysgenesis, male,
Gonadoblastoma,
Hypogonadotropic hypogonadism,
Hypoplasia of the fallopian tube,
Hypoplasia of the uterus,
Increased circulating gonadotropin level,
Infertility,
Male hypogonadism,
Male pseudohermaphroditism,
Pes cavus,
Polycystic ovaries,
Polyneuropathy,
Primary amenorrhea,
Reduced tendon reflexes,
Sensorimotor neuropathy,
Sensory ataxic neuropathy,
Sex reversal,
Skeletal muscle atrophy,
Steppage gait,
Streak ovary,
Testicular dysgenesis,
obsolete Distal sensory loss of all modalities
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Mouse (13 sources):
abnormal Sertoli cell morphology,
abnormal anogenital distance,
abnormal peritubular myoid cell morphology,
abnormal seminiferous tubule morphology,
abnormal spermatid morphology,
abnormal spermatocyte morphology,
abnormal spermatogonia morphology,
abnormal testis cord formation,
arrest of spermatogenesis,
arrest of spermiogenesis,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.