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Summary Expression Phenotypes Gene Literature (157) GO Terms (4) Nucleotides (96) Proteins (45) Interactants (736) Wiki

dvl1     dishevelled segment polarity protein 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
obsolete duplicated anterior-posterior axis (5 sources), wholly anteriorized embryo (3 sources), abnormal development of pronephric kidney (2 sources), abnormal pronephric kidney morphology (2 sources), abnormal bending of tail (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dvl1 assayed (1 source)
Computed annotations: dvl1 assayed (1 source)
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
nephronophthisis 2 (2AP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + ccdc88c + dvl1 (1 source), Xla Wt + DN-dvl1 (1 source), Xla Wt + dvl1 (1 source), Xla Wt + dvl1 (1 source), Xla Wt + dvl1 + myc-Mmu.ccdc88c (1 source), Xla Wt + dvl1 MO + dvl3 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (94 sources): Abnormal form of the vertebral bodies, Abnormal penis morphology, Abnormality of the dentition, Abnormality of the gingiva, Anodontia, Anteverted nares, Avascular necrosis of the capital femoral epiphysis, Bifid tongue, Blue sclerae, Brachydactyly, [+]
Mouse (9 sources): abnormal nest building behavior, abnormal whisker trimming behavior, behavior/neurological phenotype, decreased prepulse inhibition, decreased startle reflex, hearing/vestibular/ear phenotype, nervous system phenotype, obsolete abnormal mouse huddling behavior, reduced sensorimotor gating

View all ortholog results at Monarch