Monarch Ortholog Phenotypes
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Human (52 sources):
Abnormal C-peptide level,
Abnormal circulating fatty-acid concentration,
Abnormal insulin level,
Abnormal oral glucose tolerance,
Abnormality of the genitourinary system,
Abnormality of the kidney,
Agitation,
Coma,
Diarrhea,
Drowsiness,
Elevated circulating hepatic transaminase concentration,
Elevated hemoglobin A1c,
Exocrine pancreatic insufficiency,
Fasting hypoglycemia,
Fatigue,
Glucose intolerance,
Glycosuria,
Hepatocellular adenoma,
Hepatomegaly,
Hyperglycemia,
Hyperhidrosis,
Hyperinsulinemia,
Hyperinsulinemic hypoglycemia,
Hypoinsulinemia,
Hypoketotic hypoglycemia,
Increased body weight,
Insulin-resistant diabetes mellitus,
Intellectual disability,
Intrauterine growth retardation,
Large for gestational age,
Lethargy,
Maturity-onset diabetes of the young,
Neonatal hypoglycemia,
Neonatal hypotonia,
Nephropathy,
Obesity,
Overweight,
Pallor,
Pancreatic hypoplasia,
Pancreatic islet-cell hyperplasia,
Polycystic ovaries,
Progressive neurologic deterioration,
Renal cell carcinoma,
Renal cyst,
Retinopathy,
Seizure,
Tachycardia,
Transient neonatal diabetes mellitus,
Tremor,
Type I diabetes mellitus,
Type II diabetes mellitus,
Vomiting
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Mouse (26 sources):
abnormal energy homeostasis,
abnormal hepatocyte morphology,
abnormal pancreatic islet morphology,
abnormal renal glucose reabsorption,
abnormal sexual interaction,
abnormal stomach glandular epithelium morphology,
decreased body size,
decreased circulating insulin-like growth factor I level,
decreased insulin secretion,
decreased pancreas weight,
decreased pancreatic beta cell mass,
decreased renal glomerular filtration rate,
growth/size/body region phenotype,
homeostasis/metabolism phenotype,
increased cholesterol level,
increased circulating alanine transaminase level,
increased circulating aspartate transaminase level,
increased circulating glucose level,
increased circulating growth hormone level,
increased hepatocyte proliferation,
increased liver weight,
muscular atrophy,
premature death,
prenatal lethality, incomplete penetrance,
reproductive system phenotype,
small pancreatic islets
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View all ortholog results at Monarch
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