bmpr1a Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-485615

Gene Symbol: bmpr1a Gene Name: bone morphogenetic protein receptor type 1A

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
duplicated trunk (11 sources), obsolete duplicated anterior-posterior axis (8 sources), abnormally anterioralized embryo (5 sources), duplicated head (5 sources), abnormally localised head (4 sources), abnormal ventral tail fin morphology (3 sources), decreased pigmentation in the eye (3 sources), abnormal axis specification (2 sources), abnormally localised muscle (2 sources), abnormally localised neural tube (2 sources), wholly anteriorized tadpole (2 sources), wholly dorsalized embryo (2 sources), abnormal canonical Wnt signaling pathway (1 source), abnormal head morphology (1 source), abnormal pathway-restricted SMAD protein phosphorylation (1 source), abnormally increased number of eye (1 source), decreased length of anterior-posterior axis (1 source), decreased length of tail (1 source), duplicated main body axis (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

duplicated trunk (11 sources), obsolete duplicated anterior-posterior axis (8 sources), abnormally anterioralized embryo (5 sources), duplicated head (5 sources), abnormally localised head (4 sources), abnormal ventral tail fin morphology (3 sources), decreased pigmentation in the eye (3 sources), abnormal axis specification (2 sources), abnormally localised muscle (2 sources), abnormally localised neural tube (2 sources), wholly anteriorized tadpole (2 sources), wholly dorsalized embryo (2 sources), abnormal canonical Wnt signaling pathway (1 source), abnormal head morphology (1 source), abnormal pathway-restricted SMAD protein phosphorylation (1 source), abnormally increased number of eye (1 source), decreased length of anterior-posterior axis (1 source), decreased length of tail (1 source), duplicated main body axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: bmpr1a manipulated (18 sources), bmpr1a assayed (5 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + bmpr1a MO (6 sources), Xla Wt + bmpr1ascFv_D1 (6 sources), Xla Wt + dnbmpr1a (5 sources), Xla Wt + bmpr1a MO (4 sources), Xla Wt + bmpr1a MO (2 sources), Xla Wt + dnbmpr1a (2 sources), Xla Wt + dnbmpr1a (2 sources), Xla Wt + bmpr1a + rspo2 (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + bmpr1a MO + bmpr1b MO (1 source), Xla Wt + DN-bmpr1a (1 source), Xla Wt + mgc69520 + dnbmpr1a (1 source), Xla Wt + nog4 + dnbmpr1a (1 source), Xla Wt + nog4-EGFP + dnbmpr1a (1 source), Xla Wt + rhoa + dnbmpr1a (1 source), Xla Wt + sox17b.2 + dnbmpr1a (1 source), Xla Wt + XB5959819 [provisional] + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a + sia1 MO + sia2 MO (1 source), Xla Wt + dnbmpr1a + dnwnt8a (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + bmpr1a MO (6 sources), Xla Wt + bmpr1ascFv_D1 (6 sources), Xla Wt + dnbmpr1a (5 sources), Xla Wt + bmpr1a MO (4 sources), Xla Wt + bmpr1a MO (2 sources), Xla Wt + dnbmpr1a (2 sources), Xla Wt + dnbmpr1a (2 sources), Xla Wt + bmpr1a + rspo2 (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + bmpr1a + rspo2 MO + ventro-lateral marginal zone explant (1 source), Xla Wt + bmpr1a MO + bmpr1b MO (1 source), Xla Wt + DN-bmpr1a (1 source), Xla Wt + mgc69520 + dnbmpr1a (1 source), Xla Wt + nog4 + dnbmpr1a (1 source), Xla Wt + nog4-EGFP + dnbmpr1a (1 source), Xla Wt + rhoa + dnbmpr1a (1 source), Xla Wt + sox17b.2 + dnbmpr1a (1 source), Xla Wt + XB5959819 [provisional] + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a (1 source), Xla Wt + dnbmpr1a + sia1 MO + sia2 MO (1 source), Xla Wt + dnbmpr1a + dnwnt8a (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (33 sources): Abdominal pain, Abnormal bleeding, Adenocarcinoma of the colon, Adenomatous colonic polyposis, Anemia, Anemic pallor, Clubbing, Colon cancer, Colorectal polyposis, Desmoid tumors, Diarrhea, Duodenal adenocarcinoma, Duodenal polyposis, Edema, Endometrial carcinoma, Failure to thrive, Growth delay, Hematochezia, Hyperplastic colonic polyposis, Hypoalbuminemia, Hypokalemia, Intussusception, Juvenile colonic polyposis, Multiple gastric polyps, Neoplasm of the gastrointestinal tract, Neoplasm of the rectum, Neoplasm of the stomach, Prostate cancer, Rectal polyposis, Rectal prolapse, Refractory anemia, Small intestinal polyposis, Thyroid carcinoma [+]
Mouse (96 sources): abnormal Rathke's pouch development, abnormal articular cartilage morphology, abnormal cardiomyocyte apoptosis, abnormal cartilage development, abnormal craniofacial development, abnormal embryonic tissue morphology, abnormal embryonic-extraembryonic boundary morphology, abnormal esophageal epithelium morphology, abnormal fetal cardiomyocyte proliferation, abnormal forestomach morphology, abnormal frontonasal mesenchyme morphology, abnormal gastric gland morphology, abnormal hair follicle dermal papilla morphology, abnormal hair follicle morphology, abnormal hair follicle orientation, abnormal hair follicle regression, abnormal head mesenchyme morphology, abnormal hindlimb morphology, abnormal impulse conducting system conduction, abnormal lung epithelium morphology, abnormal mitral valve cusp morphology, abnormal nail morphology, abnormal nasal bone morphology, abnormal nasal septum morphology, abnormal neurocranium morphology, abnormal osteoclast differentiation, abnormal osteoclast physiology, abnormal pituitary gland development, abnormal pyloric gastric gland morphology, abnormal skeleton development, abnormal skeleton physiology, abnormal stomach epithelium morphology, abnormal submucosal gland morphology, abnormal suckling behavior, abnormal synovial joint membrane morphology, abnormal tail morphology, abnormal thoracic cage shape, abnormal tooth development, abnormal tricuspid valve cusp morphology, abnormal vascular branching morphogenesis, abnormal vascular development, abnormal visceral endoderm morphology, abnormal visceral yolk sac morphology, abnormal vitelline vasculature morphology, absent PR interval, absent atrioventricular cushions, absent hindlimb, absent mesoderm, absent teeth, belly spot, chondrodystrophy, decreased body size, decreased bone ossification, decreased cardiac muscle contractility, decreased cell proliferation, decreased embryo size, decreased embryonic epiblast cell proliferation, decreased grip strength, decreased osteoclast cell number, decreased survivor rate, decreased type II pneumocyte number, delayed bone ossification, ectopic digits, embryonic growth arrest, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, enlarged parietal bone, eyelids open at birth, failure of primitive streak formation, gastric polyps, hematopoietic system phenotype, increased bone mass, increased bone mineralization, increased embryonic epiblast cell apoptosis, increased hair follicle number, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, osteosclerosis, pale yolk sac, postnatal lethality, postnatal lethality, complete penetrance, premature death, prenatal lethality, preneoplasia, preweaning lethality, complete penetrance, respiratory system phenotype, secondary sex reversal, skeleton phenotype, small frontal bone, small hair follicles, small heart, small thoracic cage, thick embryonic epiblast, vascular smooth muscle hypoplasia, vision/eye phenotype [+]
View all ortholog results at Monarch