| Monarch Ortholog Phenotypes
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Human (20 sources):
Abnormal facial shape,
Absent speech,
Anxiety,
Autistic behavior,
Cerebral atrophy,
Constipation,
Feeding difficulties,
Gastroesophageal reflux,
Generalized hypotonia,
Global developmental delay,
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Mouse (25 sources):
CNS inflammation,
abnormal T-helper 2 cell morphology,
abnormal astrocyte physiology,
abnormal brain wave pattern,
abnormal cerebellar granule cell morphology,
abnormal cerebral cortex morphology,
abnormal dendritic spine morphology,
abnormal dentate gyrus morphology,
abnormal dentate gyrus neuron dendrite morphology,
abnormal hippocampus granule cell morphology,
abnormal nest building behavior,
abnormal response to social novelty,
abnormal spatial working memory,
abnormal thymus cortex morphology,
abnormal thymus lobule morphology,
abnormal thymus medulla morphology,
abnormal visual cortex morphology,
decreased neuron number,
decreased oligodendrocyte number,
decreased prepulse inhibition,
decreased single-positive T cell number,
enlarged thymus cortex,
increased dendritic spine length,
increased thermal nociceptive threshold,
thin cerebral cortex
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.