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Summary Expression Phenotypes Gene Literature (666) GO Terms (3) Nucleotides (94) Proteins (50) Interactants (964) Wiki

ins     insulin

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal protein phosphorylation (2 sources), decreased size of the proximal tubule (2 sources), decreased cell population proliferation in proximal tubule (1 source), decreased ribosomal protein S6 kinase activity (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ins assayed (13 sources)
Computed annotations: ins assayed (2 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + igf2 MO + ins MO (6 sources)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (75 sources): Abnormal C-peptide level, Abnormal heart morphology, Abnormal insulin level, Abnormal oral glucose tolerance, Abnormality of the ear, Abnormality of the genitourinary system, Abnormality of the immune system, Abnormality of the kidney, Abnormality of the upper urinary tract, Anteverted nares, [+]
Mouse (65 sources): abnormal CD8-positive, alpha beta T cell morphology, abnormal T cell proliferation, abnormal astrocyte morphology, abnormal cardiac muscle contractility, abnormal glomerular capillary morphology, abnormal kidney interstitium morphology, abnormal microglial cell morphology, abnormal pancreatic alpha cell morphology, abnormal pancreatic beta cell morphology, abnormal pancreatic beta cell physiology, [+]

View all ortholog results at Monarch