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XB-GENEPAGE-486051
lrp2 LDL receptor related protein 2
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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abnormal apical constriction (7 sources), abnormal incomplete closing of the neural fold (7 sources), abnormal neural fold morphology (6 sources), abnormal cell morphology (3 sources), increased size of the floor plate (2 sources), abnormal development of optic vesicle (1 source), abnormal establishment of planar polarity (1 source), abnormal forebrain morphology (1 source), abnormal neural plate morphology (1 source), abnormal neural tube morphology (1 source) |
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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Manual annotations: lrp2 manipulated (2 sources), lrp2 assayed (1 source) |
Computed annotations: lrp2 assayed (2 sources) |
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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Xla Wt + lrp2 MO (6 sources), Xla Wt + lrp2 MO (3 sources), Xla Wt + lrp2 CRISPR (2 sources), Xla Wt + lrp2 MO (2 sources), Xla Wt + gipc1 MO + lrp2 MO (1 source), Xla Wt + lrp2 CRISPR (1 source) |
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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Human (40 sources): Abnormality of the uterus, Aplasia/Hypoplasia of the corpus callosum, Bicornuate uterus, Broad forehead, Broad nasal tip, Cataract, Congenital diaphragmatic hernia, Depressed nasal bridge, Diaphragmatic eventration, Downslanted palpebral fissures, [+] |
Mouse (60 sources): abnormal bone mineralization, abnormal bone remodeling, abnormal cerebellum fissure morphology, abnormal cerebral cortex morphology, abnormal choroid plexus morphology, abnormal circulating mineral level, abnormal dendrite morphology, abnormal diencephalon morphology, abnormal embryonic neuroepithelium morphology, abnormal forebrain development, [+] |
View all ortholog results at Monarch |