| Monarch Ortholog Phenotypes
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Human (10 sources):
Bronchiectasis,
Bronchiolitis,
Chronic otitis media,
Chronic sinusitis,
Ectopia lentis,
Emphysema,
Nasal polyposis,
Oral ulcer,
Recurrent bronchitis,
Skin ulcer
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Mouse (22 sources):
abnormal antigen presentation,
abnormal antigen presentation via MHC class I,
abnormal blood urea nitrogen level,
abnormal dendritic cell antigen presentation,
abnormal heart rate,
abnormal lymphocyte physiology,
decreased CD8-positive, alpha-beta memory T cell number,
decreased blood urea nitrogen level,
decreased cytotoxic T cell cytolysis,
decreased double-negative T cell number,
decreased level of surface class I molecules,
decreased susceptibility to bacterial infection,
decreased susceptibility to bacterial infection induced morbidity/mortality,
defective assembly of class I molecules,
defective intracellular transport of class I molecules,
immune system phenotype,
impaired hematopoiesis,
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased T-helper 1 cell number,
increased grip strength,
increased startle reflex,
increased susceptibility to Herpesvirales infection
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.