gdf3 Phenotypes

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Phenotypes

Gene Literature (69)

Nucleotides (158)

Interactants (937)

XB-GENEPAGE-487308

Gene Symbol: gdf3 Gene Name: growth differentiation factor 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal determination of left/right symmetry (1 source), abnormal determination of left/right symmetry in lateral plate mesoderm (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: gdf3 manipulated (2 sources), gdf3 assayed (10 sources)
Computed annotations: gdf3 assayed (23 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + gdf3 MO (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (37 sources): Abnormal cardiovascular system morphology, Abnormal cranial nerve morphology, Abnormal rib morphology, Abnormal sacrum morphology, Abnormal shoulder morphology, Abnormal temporal bone morphology, Abnormal vertebral segmentation and fusion, Abnormality of the vertebral column, Anal atresia, Bilateral microphthalmos, Cervical C2/C3 vertebral fusion, Cervical C3/C4 vertebral fusion, Cervical C5/C6 vertebrae fusion, Chorioretinal coloboma, Cleft palate, Cognitive impairment, Coloboma, Congenital muscular torticollis, Ectopic anus, Facial asymmetry, Hearing impairment, Hemiplegia/hemiparesis, Hypoplasia of the fovea, Iris coloboma, Low posterior hairline, Microphthalmia, Nystagmus, Optic disc hypoplasia, Renal hypoplasia/aplasia, Scoliosis, Short neck, Spina bifida, Sprengel anomaly, Thoracic scoliosis, Ventricular septal defect, Visual impairment, Webbed neck [+]
Mouse (26 sources): abnormal anterior visceral endoderm cell migration, abnormal anterior visceral endoderm morphology, abnormal developmental patterning, abnormal endoderm development, abnormal fat cell morphology, abnormal mesoderm development, abnormal primitive streak elongation, abnormal primitive streak formation, abnormal rostral-caudal axis patterning, absent anterior visceral endoderm, absent endoderm, absent mesoderm, decreased survivor rate, decreased susceptibility to diet-induced obesity, decreased white adipose tissue amount, embryonic lethality between implantation and somite formation, incomplete penetrance, embryonic lethality, complete penetrance, embryonic-extraembryonic boundary constriction, growth/size/body region phenotype, improved glucose tolerance, increased basal metabolism, prenatal lethality, incomplete penetrance, rostral body truncation, rostral-caudal axis duplication, split notochord, thin endoderm [+]
View all ortholog results at Monarch