| Monarch Ortholog Phenotypes
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Human (38 sources):
Abnormality of cardiovascular system morphology,
Abnormality of the hypothalamus-pituitary axis,
Absent septum pellucidum,
Agenesis of corpus callosum,
Anosmia,
Anterior pituitary hypoplasia,
Aplasia/Hypoplasia of the cerebellum,
Autism,
Cleft palate,
Constipation,
Cryptorchidism,
Decreased response to growth hormone stimulation test,
Diabetes insipidus,
Dry skin,
Esophageal atresia,
Fatigue,
Global developmental delay,
Hemiplegia/hemiparesis,
Hypohidrosis,
Hypoplasia of penis,
Intellectual disability,
Maternal diabetes,
Nystagmus,
Obesity,
Optic disc hypoplasia,
Optic nerve hypoplasia,
Polydactyly,
Polydipsia,
Psychomotor retardation,
Seizure,
Sensorineural hearing impairment,
Septo-optic dysplasia,
Short finger,
Short stature,
Sleep disturbance,
Strabismus,
Tracheoesophageal fistula,
Visual impairment
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Mouse (14 sources):
abnormal neurohypophysis morphology,
abnormal paraventricular hypothalamic nucleus morphology,
abnormal pituitary hormone level,
abnormal pituitary secretion,
abnormal supraoptic nucleus morphology,
enlarged third ventricle,
increased body length,
increased body size,
increased fasting circulating glucose level,
increased liver weight,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.