pdgfb Phenotypes

XB-GENEPAGE-487582

Gene Symbol: pdgfb Gene Name: platelet derived growth factor subunit B

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: pdgfb assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (104 sources): Abnormal brain FDG positron emission tomography, Abnormal central motor function, Abnormal central sensory function, Abnormal cerebellum morphology, Abnormal hypothalamus physiology, Abnormal kinetic perimetry test, Abnormality of neuronal migration, Abnormality of the liver, Abnormality of the mediastinum, Abnormality of the sense of smell, Abnormality on pulmonary function testing, Amenorrhea, Anxiety, Apathy, Ataxia, Athetosis, Back pain, Basal ganglia calcification, Bitemporal hemianopia, Blindness, Brain stem compression, Cerebral calcification, Cerebral hemorrhage, Chorea, Chromosomal breakage induced by ionizing radiation, Cognitive impairment, Corneal opacity, Cranial nerve paralysis, Decreased circulating ACTH level, Decreased circulating cortisol level, Decreased circulating follicle stimulating hormone concentration, Decreased circulating luteinizing hormone level, Decreased serum estradiol, Decreased serum testosterone concentration, Dementia, Depression, Difficulty walking, Dysarthria, Dyskinesia, Ear pain, Emotional lability, Enlarged pituitary gland, Erythema, Excessive daytime somnolence, Facial palsy, Fibrosarcoma, Focal T2 hypointense thalamic lesion, Focal-onset seizure, Functional motor deficit, Headache, Hemifacial spasm, Hemiparesis, Hepatomegaly, Hydrocephalus, Hypogonadotropic hypogonadism, Hypothalamic hypothyroidism, Impotence, Increased circulating prolactin concentration, Increased intracranial pressure, Increased sensitivity to ionizing radiation, Intracranial meningioma, Intrauterine growth retardation, Lower limb muscle weakness, Memory impairment, Meningioma, Microcephaly, Migraine, Motor tics, Nausea and vomiting, Neoplasm of the anterior pituitary, Neoplasm of the posterior pituitary, Neoplasm of the skin, Neoplasm of the tongue, Neurofibromas, Neurological speech impairment, Obesity, Oculomotor nerve palsy, Ophthalmoplegia, Papilledema, Parkinsonism, Pituitary hypothyroidism, Progressive pulmonary function impairment, Proptosis, Psychosis, Reduced circulating prolactin concentration, Secondary growth hormone deficiency, Seizure, Skin ulcer, Slow decrease in visual acuity, Spinal meningioma, Subcutaneous hemorrhage, Subcutaneous nodule, Syncope, Thickened skin, Thrombocytopenia, Tinnitus, Transient global amnesia, Trigeminal neuralgia, Upper limb muscle weakness, Urinary incontinence, Ventriculomegaly, Vertigo, Visual acuity test abnormality, Weak extraocular muscles [+]
Mouse (41 sources): abnormal aorta smooth muscle morphology, abnormal artery morphology, abnormal astrocyte morphology, abnormal blood-brain barrier function, abnormal coronary vessel morphology, abnormal glial cell morphology, abnormal glomerular mesangium morphology, abnormal kidney morphology, abnormal microglial cell morphology, abnormal pericyte morphology, abnormal placenta vasculature, abnormal placental labyrinth vasculature morphology, abnormal renal glomerulus morphology, abnormal retina neuronal layer morphology, abnormal retina photoreceptor layer morphology, abnormal retina pigment epithelium morphology, abnormal retina vasculature morphology, abnormal trophoblast layer morphology, abnormal vascular endothelial cell morphology, abnormal vascular smooth muscle morphology, absent mesangial cell, brain aneurysm, decreased capillary density, decreased hematocrit, decreased hemoglobin content, decreased mesangial cell number, dilated glomerular capillary, dilated heart left ventricle, erythroblastosis, increased capillary tortuosity, increased vascular endothelial cell number, kidney microaneurysm, lethality throughout fetal growth and development, incomplete penetrance, perinatal lethality, complete penetrance, perinatal lethality, incomplete penetrance, reduced female fertility, retina fibrosis, skin edema, small kidney, small liver, thin myocardium [+]
View all ortholog results at Monarch