| Monarch Ortholog Phenotypes
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Human (22 sources):
Abdominal distention,
Abnormal renal tubule morphology,
Congenital nephrotic syndrome,
Delayed eruption of permanent teeth,
Diffuse mesangial sclerosis,
Edema,
Elevated amniotic fluid alpha-fetoprotein,
Gastroesophageal reflux,
Glomerular sclerosis,
Growth delay,
Hyperlipidemia,
Hypoalbuminemia,
Hypoproteinemia,
Hypothyroidism,
Neonatal respiratory distress,
Nephrotic syndrome,
Proteinuria,
Pyloric stenosis,
Recurrent infections,
Renal insufficiency,
Renal tubular atrophy,
Small for gestational age
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Mouse (22 sources):
abnormal kidney morphology,
abnormal podocyte foot process morphology,
abnormal podocyte slit diaphragm morphology,
abnormal podocyte slit junction morphology,
abnormal renal glomerulus morphology,
abnormal renal reabsorption,
absent podocyte slit diaphragm,
dilated distal convoluted tubule,
dilated proximal convoluted tubule,
dilated renal glomerular capsule,
dilated renal tubules,
fused podocyte foot processes,
increased glomerular capsule space,
increased kidney weight,
increased mesangial cell number,
kidney medulla cyst,
neonatal lethality, incomplete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
podocyte foot process effacement,
postnatal lethality, complete penetrance
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.